Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

• Published in: Gut microbes Vol. 13; no. 1; p. 1
• Main Authors: Rao, Yong, Kuang, Zhiqi, Li, Chan, Guo, Shiyao, Xu, Yaohao, Zhao, Dandan, Hu, Yutao, Song, Bingbing, Jiang, Zhi, Ge, Zhenhuang, Liu, Xiyuan, Li, Chengdao, Chen, Shuobin, Ye, Jiming, Huang, Zhishu, Lu, Yongjun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: Akkermansia - genetics; Akkermansia - metabolism; Akkermansia muciniphila; Animals; Aspartic Acid - metabolism; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; bile acid metabolism; Diet, High-Fat - adverse effects; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - microbiology; Gastrointestinal Microbiome; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - microbiology; gut-liver axis; Humans; L-aspartate; lipid oxidation; Liver - metabolism; Male; Metabolic-dysfunction associated fatty liver disease (MAFLD); Mice; Mice, Inbred C57BL; Research Paper; bile acid metabolism; lipid oxidation; L-aspartate; Akkermansia muciniphila; Metabolic-dysfunction associated fatty liver disease (MAFLD); gut-liver axis

The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-associated fatty liver disease (MAFLD). However, its underlying mechanism involved in its well-known metabol...