Blockade of adrenoreceptors inhibits the splenic response to stroke

• Published in: Experimental neurology Vol. 218; no. 1; pp. 47 - 55
• Main Authors: Ajmo, Craig T., Collier, Lisa A., Leonardo, Christopher C., Hall, Aaron A., Green, Suzanne M., Womble, Tracy A., Cuevas, Javier, Willing, Alison E., Pennypacker, Keith R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2009; Elsevier
• Subjects: Adrenergic alpha-Antagonists; Adrenergic Antagonists - pharmacology; Adrenergic beta-Antagonists - pharmacology; Animals; Biological and medical sciences; Carbazoles - pharmacology; Cytokines - metabolism; Denervation - methods; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fetal Blood - cytology; Flow Cytometry - methods; Humans; Infarction, Middle Cerebral Artery - pathology; Male; Medical sciences; Neurology; Propanolamines - pharmacology; Propranolol - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic - metabolism; Spleen - drug effects; Spleen - immunology; Spleen - pathology; Tyrosine 3-Monooxygenase - genetics; Tyrosine 3-Monooxygenase - metabolism; Vascular diseases and vascular malformations of the nervous system; Vascular disease; Stroke; Nervous system diseases; Central nervous system disease; Cardiovascular disease; Cerebrovascular disease; Cerebral disorder

Recent studies have highlighted the involvement of the peripheral immune system in delayed cellular degeneration after stroke. In the permanent middle cerebral artery occlusion (MCAO) model of stroke, the spleen decreases in size. This reduction occurs through the release of splenic immune cells. Sy...