Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

• Published in: Gut microbes Vol. 14; no. 1; p. 2063016
• Main Authors: Mujagic, Zlatan, Kasapi, Melpomeni, Jonkers, Daisy MAE, Garcia-Perez, Isabel, Vork, Lisa, Weerts, Zsa Zsa R.M., Serrano-Contreras, Jose Ivan, Zhernakova, Alexandra, Kurilshikov, Alexander, Scotcher, Jamie, Holmes, Elaine, Wijmenga, Cisca, Keszthelyi, Daniel, Nicholson, Jeremy K, Posma, Joram M, Masclee, Ad AM
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: fecal metabolome; Feces - chemistry; Gastrointestinal Microbiome - physiology; gut metabolome; gut microbiota; gut-brain; host-microbiome interaction; Humans; Irritable bowel syndrome; Irritable Bowel Syndrome - metabolism; Metabolome; microbiome; Microbiota; Research Paper; serotonin; Serotonin - metabolism; stress; gut metabolome; stress; serotonin; gut-brain; Irritable bowel syndrome; host-microbiome interaction; fecal metabolome; microbiome; gut microbiota
• ISSN: 1949-0976; 1949-0984; 1949-0984
• DOI: 10.1080/19490976.2022.2063016

To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles of fecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that re...