GDNF family ligand receptor components Ret and GFRalpha-1 in the human trigeminal ganglion and sensory nuclei

• Published in: Brain research bulletin Vol. 69; no. 4; pp. 393 - 403
• Main Authors: Quartu, Marina, Serra, Maria Pina, Mascia, Francesca, Boi, Marianna, Lai, Maria Letizia, Spano, Alessia, Del Fiacco, Marina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.04.2006
• Subjects: Adult; Adulthood; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide - metabolism; CGRP; Colocalization; Development; Fetus - metabolism; GDNF receptors; Glial Cell Line-Derived Neurotrophic Factor - metabolism; Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism; Humans; Immunohistochemistry; Infant; Infant, Newborn; Man; Middle Aged; Proto-Oncogene Proteins c-ret - metabolism; Trigeminal Ganglion - embryology; Trigeminal Ganglion - growth & development; Trigeminal Ganglion - metabolism; Trigeminal Nuclei - embryology; Trigeminal Nuclei - growth & development; Trigeminal Nuclei - metabolism; Trigeminal sensory system; Colocalization; Trigeminal sensory system; GDNF receptors; Development; Man; Adulthood; CGRP

The occurrence of Ret and GFRalpha-1 receptors is shown by immunohistochemistry in the human trigeminal sensory system at pre-, postnatal and adult age. Receptor-labeled neurons occur in both trigeminal ganglion and mesencephalic nucleus. In adult trigeminal ganglion, about 75% of Ret- and 65% of GF...