Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development

• Published in: Autophagy Vol. 16; no. 4; pp. 709 - 723
• Main Authors: Unno, Rei, Kawabata, Tsuyoshi, Taguchi, Kazumi, Sugino, Teruaki, Hamamoto, Shuzo, Ando, Ryosuke, Okada, Atsushi, Kohri, Kenjiro, Yoshimori, Tamotsu, Yasui, Takahiro
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.04.2020
• Subjects: Autophagy; calcium oxalate; kidney stone; mechanistic target of rapamycin kinase; Research Paper; transcription factor EB; transcription factor EB; calcium oxalate; kidney stone; Autophagy; mechanistic target of rapamycin kinase

Kidney stone disease is a lifestyle-related disease prevalent in developed countries; however, effective medical treatment for the disease is not yet well established. As cellular damage in renal tubular cells (RTCs) is responsible for the disease, here, we focused on the role of macroautophagy/auto...