Inducible gene expression: diverse regulatory mechanisms

• Published in: Nature reviews. Genetics Vol. 11; no. 6; pp. 426 - 437
• Main Authors: Weake, Vikki M., Workman, Jerry L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2010; Nature Publishing Group
• Subjects: 631/208/200; Agriculture; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromatin Assembly and Disassembly - genetics; Chromatin Assembly and Disassembly - physiology; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Function; Gene Regulatory Networks - physiology; Genetics of eukaryotes. Biological and molecular evolution; Human Genetics; Humans; Kinases; Models, Biological; Phosphorylation; Phosphotransferases - metabolism; Phosphotransferases - physiology; Physiological aspects; Promoters (Genetics); Proteins; Recruitment; review-article; RNA polymerase; RNA polymerases; Signal transduction; Signal Transduction - genetics; Transcription factors; Transcription Factors - metabolism; Transcription Factors - physiology; Transcription, Genetic - genetics; Transcription, Genetic - physiology; Transcriptional Activation - physiology; Yeast; United States; Gene expression; Mechanism; Review

Key Points Expression of target genes in response to extracellular stimuli is activated by means that include activation of RNA polymerase II (Pol II)-dependent transcription. Multiple processes during the early stages of Pol II-dependent transcription are subject to regulation and can therefore fun...