Blocking NOTCH pathway can enhance the effect of EGFR inhibitor through targeting CD133+ endometrial cancer cells - Shang, Chao; Lang, Bin; Meng, Li-rong (Cancer biology & therapy, 2018)
Keywords: AC133 Antigen - metabolism; Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cancer stem cell; Carcinogenesis - drug effects; Carcinogenesis - pathology; Cell Line, Tumor; Diamines - pharmacology; Diamines - therapeutic use; Drug Resistance, Neoplasm - drug effects; Drug Synergism; EGFR; endometrial cancer; Endometrial Neoplasms - drug therapy; Endometrial Neoplasms - pathology; ErbB Receptors - antagonists & inhibitors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; NOTCH; Quinazolines - pharmacology; Quinazolines - therapeutic use; Receptors, Notch - antagonists & inhibitors; Receptors, Notch - metabolism; Research Papers; Signal Transduction - drug effects; Thiazoles - pharmacology; Thiazoles - therapeutic use; Tyrphostins - pharmacology; Tyrphostins - therapeutic use; Xenograft Model Antitumor Assays; Cancer stem cell; NOTCH; endometrial cancer; EGFR