Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 26; no. 6; pp. 789 - 793
• Main Authors: Westberg, Lars, Bah, Jessica, Råstam, Maria, Gillberg, Christopher, Wentz, Elisabet, Melke, Jonas, Hellstrand, Monika, Eriksson, Elias
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2002; Nature Publishing; Nature Publishing Group
• Subjects: 5-HT2C; 5-HT2C receptor; Adolescent; Adolescent - physiology; Adult and adolescent clinical studies; Anorexia; Anorexia nervosa; Biological and medical sciences; Chi-Square Distribution; Child & adolescent psychiatry; Eating behavior disorders; Eating disorder; Farmakologi och toxikologi; Feeding Behavior; Feeding Behavior - physiology; Female; Food; Genetic; Genetics; Humans; Medical sciences; Pharmacology and Toxicology; physiology; Polymorphism; Polymorphism, Genetic - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptor; Receptor, Serotonin, 5-HT2C; Receptors; Receptors, Serotonin - genetics; Serotonin; Weight Loss; Weight Loss - genetics; Sweden; Genetics; 5-HT2C receptor; Anorexia nervosa; Serotonin; Eating disorder; Polymorphism; Human; Healthy subject; Weight loss; Genotype; Allele; Gene; Adolescent; Predisposition; Female; 5-HT2C serotonin receptor

Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weig...