BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming

• Published in: Autophagy Vol. 13; no. 9; pp. 1543 - 1555
• Main Authors: Xiang, Ge, Yang, Liang, Long, Qi, Chen, Keshi, Tang, Haite, Wu, Yi, Liu, Zihuang, Zhou, Yanshuang, Qi, Juntao, Zheng, Lingjun, Liu, Wenbo, Ying, Zhongfu, Fan, Weimin, Shi, Hongyan, Li, Hongmei, Lin, Xiaobing, Gao, Mi, Liu, Jinglei, Bao, Feixiang, Li, Linpeng, Duan, Lifan, Li, Min, Liu, Xingguo
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.09.2017
• Subjects: Animals; autophagy; Basic Research Paper; BNIP3L; Cellular Reprogramming; Embryo, Mammalian - cytology; endosome; Endosomes - metabolism; Endosomes - ultrastructure; Fibroblasts - metabolism; Membrane Potential, Mitochondrial; Membrane Proteins - metabolism; Mice; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitochondrial Degradation; Mitochondrial Proteins - metabolism; mitophagy; Models, Biological; rab5 GTP-Binding Proteins - metabolism; reprogramming; Transcription Factors - metabolism; reprogramming; BNIP3L; endosome; mitophagy; autophagy

Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during s...