Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity

• Published in: iScience Vol. 9; pp. 229 - 243
• Main Authors: Salazar, Anna M., Resnik-Docampo, Martin, Ulgherait, Matthew, Clark, Rebecca I., Shirasu-Hiza, Mimi, Jones, D. Leanne, Walker, David W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 30.11.2018
• Subjects: Molecular Mechanism of Behavior; Model Organism; Functional Aspects of Cell Biology; Microbiome

Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan de...