Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity
Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan de...
Saved in:
| Published in | iScience Vol. 9; pp. 229 - 243 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier
30.11.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila. Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals. |
|---|---|
| AbstractList | Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila. Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals. Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila . Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals. • Loss of Ssk leads to intestinal barrier dysfunction, dysbiosis, and early-onset death • Restoration of Ssk reverses each of these age-associated phenotypes • Up-regulation of Ssk prevents bacterial translocation upon pathogenic infection • Ssk up-regulation improves barrier integrity, limits dysbiosis, and extends lifespan Molecular Mechanism of Behavior; Microbiome; Functional Aspects of Cell Biology; Model Organism Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila. Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals. : Molecular Mechanism of Behavior; Microbiome; Functional Aspects of Cell Biology; Model Organism Subject Areas: Molecular Mechanism of Behavior, Microbiome, Functional Aspects of Cell Biology, Model Organism Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila. Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals.Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan in Drosophila. Loss of Ssk leads to rapid and reversible intestinal barrier dysfunction, altered gut morphology, dysbiosis, and dramatically reduced lifespan. Remarkably, restoration of Ssk expression in flies showing intestinal barrier dysfunction rescues each of these phenotypes previously linked to aging. Intestinal up-regulation of Ssk protects against microbial translocation following oral infection with pathogenic bacteria. Furthermore, intestinal up-regulation of Ssk improves intestinal barrier function during aging, limits dysbiosis, and extends lifespan. Our findings indicate that intestinal occluding junctions may represent prolongevity targets in mammals. |
| Author | Salazar, Anna M. Jones, D. Leanne Ulgherait, Matthew Clark, Rebecca I. Resnik-Docampo, Martin Walker, David W. Shirasu-Hiza, Mimi |
| AuthorAffiliation | 1 Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA 6 Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA 3 Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA 4 Department of Biosciences, Durham University, Durham DH1 3LE, UK 5 Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA 2 Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA |
| AuthorAffiliation_xml | – name: 1 Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA – name: 4 Department of Biosciences, Durham University, Durham DH1 3LE, UK – name: 6 Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA – name: 3 Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA – name: 5 Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA – name: 2 Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA |
| Author_xml | – sequence: 1 givenname: Anna M. surname: Salazar fullname: Salazar, Anna M. – sequence: 2 givenname: Martin surname: Resnik-Docampo fullname: Resnik-Docampo, Martin – sequence: 3 givenname: Matthew surname: Ulgherait fullname: Ulgherait, Matthew – sequence: 4 givenname: Rebecca I. surname: Clark fullname: Clark, Rebecca I. – sequence: 5 givenname: Mimi surname: Shirasu-Hiza fullname: Shirasu-Hiza, Mimi – sequence: 6 givenname: D. Leanne surname: Jones fullname: Jones, D. Leanne – sequence: 7 givenname: David W. surname: Walker fullname: Walker, David W. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30419503$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU1r3DAQhkVJaT6aP9BD8bGX3erLsnQphKQfC1taSHsWkj12Z-OVUskb2H9fOZuGpIeCkIaZd54R856SoxADEPKG0SWjTL3fLDG3uOSU6ZJYUs5fkBNea7OgVPKjJ_ExOc95Qynl5UijXpFjQSUzNRUn5HoVJsgTBjdW18HdQL7BUK1xi1OuvmKbosdSutpnjzFjrrpdwjBUF8N8u9BV31PcxsKo1jEMcIfT_jV52bsxw_nDe0Z-fvr44_LLYv3t8-ryYr1oayGnhfAeZNtLyoVxtWlozZz2SjS9A-6M0kb6ugUlmGZadQDQdJ0zWkDXUCmNOCOrA7eLbmNvE25d2tvo0N4nYhqsSxO2I9hW-Vr11HSykVI32jRK9UbXyjsAL1VhfTiwbnd-C10LYUpufAZ9Xgn4yw7xziouGNWyAN49AFL8vSsrtdtiEIyjCxB32XImeMO15E2Rvn0663HIX1eKgB8EZf05J-gfJYza2X27sbP7dnZ_zhX3S5P-p6nFyU0Y5__i-L_WP8C1trA |
| CitedBy_id | crossref_primary_10_1186_s12915_024_01956_4 crossref_primary_10_7554_eLife_77441 crossref_primary_10_18632_aging_102073 crossref_primary_10_1242_dmm_049969 crossref_primary_10_1016_j_carbpol_2022_120467 crossref_primary_10_1128_spectrum_03639_23 crossref_primary_10_1038_s43587_022_00308_7 crossref_primary_10_3390_ijms21176362 crossref_primary_10_1002_wdev_378 crossref_primary_10_1016_j_stemcr_2020_03_021 crossref_primary_10_1111_apha_13527 crossref_primary_10_1038_s41380_022_01680_x crossref_primary_10_1038_s41467_021_24585_9 crossref_primary_10_3389_fragi_2022_909509 crossref_primary_10_1016_j_stemcr_2021_04_006 crossref_primary_10_1242_jcs_232108 crossref_primary_10_3389_fimmu_2019_03075 crossref_primary_10_1073_pnas_2311313121 crossref_primary_10_1016_j_celrep_2021_109564 crossref_primary_10_1016_j_isci_2023_106901 crossref_primary_10_1038_s43587_022_00278_w crossref_primary_10_1073_pnas_1913976117 crossref_primary_10_1002_arch_22033 crossref_primary_10_1016_j_mad_2020_111285 crossref_primary_10_14336_AD_2020_1008 crossref_primary_10_15252_embr_202050047 crossref_primary_10_1016_j_cois_2021_02_001 crossref_primary_10_7554_eLife_62233 crossref_primary_10_1242_jcs_261118 crossref_primary_10_59368_agingbio_20240024 crossref_primary_10_1016_j_isci_2021_102150 crossref_primary_10_34133_research_0343 crossref_primary_10_1038_s43587_020_00013_3 crossref_primary_10_3390_microorganisms9050958 crossref_primary_10_1016_j_bbamem_2019_183143 crossref_primary_10_1242_jcs_257022 crossref_primary_10_1007_s10522_023_10049_8 crossref_primary_10_1039_D1FO03396D crossref_primary_10_1152_ajpcell_00492_2019 crossref_primary_10_1242_bio_056515 |
| Cites_doi | 10.1007/s00018-017-2671-1 10.1016/j.bbadis.2012.04.012 10.1038/nmicrobiol.2017.20 10.18632/aging.100054 10.1111/nyas.13366 10.1038/nature04333 10.1016/j.devcel.2008.12.015 10.1038/nrgastro.2016.169 10.1042/BJ20091181 10.1006/dbio.1994.1054 10.1101/gad.1827009 10.1016/j.yexcr.2017.03.036 10.1016/j.ceb.2012.01.004 10.1016/j.celrep.2015.08.004 10.1016/j.chom.2017.03.002 10.1093/gerona/62.10.1071 10.1016/j.stem.2008.07.024 10.1007/s12603-016-0725-y 10.1093/gerona/glt106 10.1038/srep23523 10.1046/j.1440-1746.2003.03032.x 10.1242/jcs.112243 10.1038/ni.1765 10.1371/journal.ppat.0030173 10.1038/ncb3454 10.1242/jcs.096800 10.1016/j.cell.2013.12.018 10.1111/j.1572-0241.2002.05914.x 10.1126/science.1181958 10.1159/000228556 10.1126/science.1117311 10.1016/j.cell.2009.05.014 10.1038/ni0909-936 10.1080/19336934.2018.1441651 10.1371/journal.pgen.1006135 10.1016/j.cub.2017.01.035 10.1038/nrg2468 10.1038/nature04371 10.1016/j.arr.2012.05.003 10.1111/j.1474-9726.2008.00380.x 10.1007/s40520-013-0148-0 10.1080/07924259.2014.963713 10.1016/j.crohns.2011.10.004 10.1016/j.cmet.2011.09.013 10.2174/1381612822666160510125331 10.1073/pnas.1215849110 10.1101/cshperspect.a029314 |
| ContentType | Journal Article |
| Copyright | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. 2018 The Authors 2018 |
| Copyright_xml | – notice: Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. – notice: 2018 The Authors 2018 |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1016/j.isci.2018.10.022 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2589-0042 |
| EndPage | 243 |
| ExternalDocumentID | oai_doaj_org_article_c6b56f09d47448789766f9856baeeb46 PMC6231084 30419503 10_1016_j_isci_2018_10_022 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: R01 AG049157 – fundername: NIDDK NIH HHS grantid: T32 DK007328 – fundername: NIA NIH HHS grantid: R01 AG045842 – fundername: NIDDK NIH HHS grantid: R01 DK105442 – fundername: NIGMS NIH HHS grantid: R35 GM127049 – fundername: NIA NIH HHS grantid: R01 AG028092 |
| GroupedDBID | 0R~ 53G AAEDW AALRI AAMRU AAXUO AAYWO AAYXX ABMAC ACVFH ADBBV ADCNI ADVLN AEUPX AEXQZ AFPUW AFTJW AIGII AITUG AKBMS AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV CITATION EBS EJD FDB GROUPED_DOAJ HYE M41 OK1 ROL RPM SSZ NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c534t-3bbe4cf40239a597051a8b637fae2a96894b5ce6318186deee7dda983ed704493 |
| IEDL.DBID | DOA |
| ISSN | 2589-0042 |
| IngestDate | Wed Aug 27 01:30:22 EDT 2025 Thu Aug 21 13:33:49 EDT 2025 Fri Jul 11 02:00:24 EDT 2025 Mon Jul 21 06:04:29 EDT 2025 Tue Jul 01 01:03:24 EDT 2025 Thu Apr 24 22:57:52 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Molecular Mechanism of Behavior Model Organism Functional Aspects of Cell Biology Microbiome |
| Language | English |
| License | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c534t-3bbe4cf40239a597051a8b637fae2a96894b5ce6318186deee7dda983ed704493 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead Contact |
| OpenAccessLink | https://doaj.org/article/c6b56f09d47448789766f9856baeeb46 |
| PMID | 30419503 |
| PQID | 2132728427 |
| PQPubID | 23479 |
| PageCount | 15 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c6b56f09d47448789766f9856baeeb46 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6231084 proquest_miscellaneous_2132728427 pubmed_primary_30419503 crossref_primary_10_1016_j_isci_2018_10_022 crossref_citationtrail_10_1016_j_isci_2018_10_022 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-11-30 |
| PublicationDateYYYYMMDD | 2018-11-30 |
| PublicationDate_xml | – month: 11 year: 2018 text: 2018-11-30 day: 30 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | iScience |
| PublicationTitleAlternate | iScience |
| PublicationYear | 2018 |
| Publisher | Elsevier |
| Publisher_xml | – name: Elsevier |
| References | Rera (10.1016/j.isci.2018.10.022_bib41) 2012; 109 Bass (10.1016/j.isci.2018.10.022_bib1) 2007; 62 Buckley (10.1016/j.isci.2018.10.022_bib6) 2018; 10 Meier (10.1016/j.isci.2018.10.022_bib29) 2009; 27 Jasper (10.1016/j.isci.2018.10.022_bib24) 2015; 59 Farhadi (10.1016/j.isci.2018.10.022_bib15) 2003; 18 Mitchell (10.1016/j.isci.2018.10.022_bib31) 2017; 21 Yanagihashi (10.1016/j.isci.2018.10.022_bib52) 2012; 125 Resende (10.1016/j.isci.2018.10.022_bib42) 2012; 24 Guo (10.1016/j.isci.2018.10.022_bib18) 2014; 156 Ha (10.1016/j.isci.2018.10.022_bib20) 2009; 10 Lusis (10.1016/j.isci.2018.10.022_bib27) 2008; 9 Tepass (10.1016/j.isci.2018.10.022_bib47) 1994; 161 Leulier (10.1016/j.isci.2018.10.022_bib26) 2009; 10 Choi (10.1016/j.isci.2018.10.022_bib10) 2017; 358 Resnik-Docampo (10.1016/j.isci.2018.10.022_bib43) 2017; 19 Nehme (10.1016/j.isci.2018.10.022_bib33) 2007; 3 Xiao (10.1016/j.isci.2018.10.022_bib51) 2017; 2 Hu (10.1016/j.isci.2018.10.022_bib22) 2017; 27 Noth (10.1016/j.isci.2018.10.022_bib34) 2012; 6 Suenaert (10.1016/j.isci.2018.10.022_bib45) 2002; 97 Micchelli (10.1016/j.isci.2018.10.022_bib30) 2006; 439 Choi (10.1016/j.isci.2018.10.022_bib9) 2008; 7 Gelino (10.1016/j.isci.2018.10.022_bib17) 2016; 12 Ha (10.1016/j.isci.2018.10.022_bib19) 2009; 16 Mathur (10.1016/j.isci.2018.10.022_bib28) 2010; 327 Resnik-Docampo (10.1016/j.isci.2018.10.022_bib44) 2018; 12 Odenwald (10.1016/j.isci.2018.10.022_bib35) 2017; 14 Thevaranjan (10.1016/j.isci.2018.10.022_bib48) 2017; 21 Cesar Machado (10.1016/j.isci.2018.10.022_bib8) 2016; 22 Clark (10.1016/j.isci.2018.10.022_bib12) 2015; 12 Rera (10.1016/j.isci.2018.10.022_bib39) 2013; 12 Teleman (10.1016/j.isci.2018.10.022_bib46) 2009; 425 Dambroise (10.1016/j.isci.2018.10.022_bib14) 2016; 6 Rera (10.1016/j.isci.2018.10.022_bib40) 2011; 14 Buchon (10.1016/j.isci.2018.10.022_bib5) 2009; 23 Ren (10.1016/j.isci.2018.10.022_bib38) 2014; 26 Ohlstein (10.1016/j.isci.2018.10.022_bib36) 2006; 439 Tran (10.1016/j.isci.2018.10.022_bib49) 2013; 68 Clark (10.1016/j.isci.2018.10.022_bib13) 2018; 75 Biteau (10.1016/j.isci.2018.10.022_bib2) 2008; 3 Izumi (10.1016/j.isci.2018.10.022_bib23) 2012; 125 Jiang (10.1016/j.isci.2018.10.022_bib25) 2009; 137 Furuse (10.1016/j.isci.2018.10.022_bib16) 2017; 1397 Morris (10.1016/j.isci.2018.10.022_bib32) 2012; 1822 Ha (10.1016/j.isci.2018.10.022_bib21) 2005; 310 Park (10.1016/j.isci.2018.10.022_bib37) 2009; 1 |
| References_xml | – volume: 75 start-page: 93 year: 2018 ident: 10.1016/j.isci.2018.10.022_bib13 article-title: Role of gut microbiota in aging-related health decline: insights from invertebrate models publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-017-2671-1 – volume: 1822 start-page: 1230 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib32 article-title: Development of diet-induced insulin resistance in adult Drosophila melanogaster publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2012.04.012 – volume: 2 start-page: 17020 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib51 article-title: A Mesh-Duox pathway regulates homeostasis in the insect gut publication-title: Nat. Microbiol. doi: 10.1038/nmicrobiol.2017.20 – volume: 1 start-page: 637 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib37 article-title: The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila publication-title: Aging doi: 10.18632/aging.100054 – volume: 1397 start-page: 17 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib16 article-title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology publication-title: Ann. N. Y Acad. Sci. doi: 10.1111/nyas.13366 – volume: 439 start-page: 470 year: 2006 ident: 10.1016/j.isci.2018.10.022_bib36 article-title: The adult Drosophila posterior midgut is maintained by pluripotent stem cells publication-title: Nature doi: 10.1038/nature04333 – volume: 16 start-page: 386 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib19 article-title: Regulation of DUOX by the galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.12.015 – volume: 14 start-page: 9 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib35 article-title: The intestinal epithelial barrier: a therapeutic target? publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2016.169 – volume: 425 start-page: 13 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib46 article-title: Molecular mechanisms of metabolic regulation by insulin in Drosophila publication-title: Biochem. J. doi: 10.1042/BJ20091181 – volume: 161 start-page: 563 year: 1994 ident: 10.1016/j.isci.2018.10.022_bib47 article-title: The development of cellular junctions in the Drosophila embryo publication-title: Dev. Biol. doi: 10.1006/dbio.1994.1054 – volume: 23 start-page: 2333 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib5 article-title: Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila publication-title: Genes Dev. doi: 10.1101/gad.1827009 – volume: 358 start-page: 71 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib10 article-title: Contributions of intestinal epithelial barriers to health and disease publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2017.03.036 – volume: 24 start-page: 225 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib42 article-title: Local signaling within stem cell niches: insights from Drosophila publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2012.01.004 – volume: 12 start-page: 1656 year: 2015 ident: 10.1016/j.isci.2018.10.022_bib12 article-title: Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.08.004 – volume: 21 start-page: 455 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib48 article-title: Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction publication-title: Cell Host Microbe doi: 10.1016/j.chom.2017.03.002 – volume: 62 start-page: 1071 year: 2007 ident: 10.1016/j.isci.2018.10.022_bib1 article-title: Optimization of dietary restriction protocols in Drosophila publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/62.10.1071 – volume: 3 start-page: 442 year: 2008 ident: 10.1016/j.isci.2018.10.022_bib2 article-title: JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.07.024 – volume: 21 start-page: 354 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib31 article-title: Reduced Intestinal motility, mucosal barrier function, and inflammation in aged monkeys publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-016-0725-y – volume: 68 start-page: 1045 year: 2013 ident: 10.1016/j.isci.2018.10.022_bib49 article-title: Age-associated remodeling of the intestinal epithelial barrier publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glt106 – volume: 6 start-page: 23523 year: 2016 ident: 10.1016/j.isci.2018.10.022_bib14 article-title: Two phases of aging separated by the Smurf transition as a public path to death publication-title: Sci. Rep. doi: 10.1038/srep23523 – volume: 18 start-page: 479 year: 2003 ident: 10.1016/j.isci.2018.10.022_bib15 article-title: Intestinal barrier: an interface between health and disease publication-title: J. Gastroenterol. Hepatol. doi: 10.1046/j.1440-1746.2003.03032.x – volume: 125 start-page: 4923 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib23 article-title: A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut publication-title: J. Cell Sci. doi: 10.1242/jcs.112243 – volume: 10 start-page: 949 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib20 article-title: Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in Drosophila gut publication-title: Nat. Immunol. doi: 10.1038/ni.1765 – volume: 3 start-page: e173 year: 2007 ident: 10.1016/j.isci.2018.10.022_bib33 article-title: A model of bacterial intestinal infections in Drosophila melanogaster publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.0030173 – volume: 19 start-page: 52 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib43 article-title: Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis publication-title: Nat. Cell Biol. doi: 10.1038/ncb3454 – volume: 125 start-page: 1980 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib52 article-title: Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila publication-title: J. Cell Sci. doi: 10.1242/jcs.096800 – volume: 156 start-page: 109 year: 2014 ident: 10.1016/j.isci.2018.10.022_bib18 article-title: PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan publication-title: Cell doi: 10.1016/j.cell.2013.12.018 – volume: 97 start-page: 2000 year: 2002 ident: 10.1016/j.isci.2018.10.022_bib45 article-title: Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2002.05914.x – volume: 327 start-page: 210 year: 2010 ident: 10.1016/j.isci.2018.10.022_bib28 article-title: A transient niche regulates the specification of Drosophila intestinal stem cells publication-title: Science doi: 10.1126/science.1181958 – volume: 27 start-page: 240 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib29 article-title: The intestinal epithelial barrier: does it become impaired with age? publication-title: Dig. Dis. doi: 10.1159/000228556 – volume: 310 start-page: 847 year: 2005 ident: 10.1016/j.isci.2018.10.022_bib21 article-title: A direct role for dual oxidase in Drosophila gut immunity publication-title: Science doi: 10.1126/science.1117311 – volume: 137 start-page: 1343 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib25 article-title: Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut publication-title: Cell doi: 10.1016/j.cell.2009.05.014 – volume: 10 start-page: 936 year: 2009 ident: 10.1016/j.isci.2018.10.022_bib26 article-title: Maintaining immune homeostasis in fly gut publication-title: Nat. Immunol. doi: 10.1038/ni0909-936 – volume: 12 start-page: 1 year: 2018 ident: 10.1016/j.isci.2018.10.022_bib44 article-title: Keeping it tight: the relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila publication-title: Fly (Austin) doi: 10.1080/19336934.2018.1441651 – volume: 12 start-page: e1006135 year: 2016 ident: 10.1016/j.isci.2018.10.022_bib17 article-title: Intestinal autophagy improves healthspan and longevity in C. elegans during dietary restriction publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006135 – volume: 27 start-page: R185 year: 2017 ident: 10.1016/j.isci.2018.10.022_bib22 article-title: Epithelia: understanding the cell biology of intestinal barrier dysfunction publication-title: Curr. Biol. doi: 10.1016/j.cub.2017.01.035 – volume: 9 start-page: 819 year: 2008 ident: 10.1016/j.isci.2018.10.022_bib27 article-title: Metabolic syndrome: from epidemiology to systems biology publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2468 – volume: 439 start-page: 475 year: 2006 ident: 10.1016/j.isci.2018.10.022_bib30 article-title: Evidence that stem cells reside in the adult Drosophila midgut epithelium publication-title: Nature doi: 10.1038/nature04371 – volume: 12 start-page: 436 year: 2013 ident: 10.1016/j.isci.2018.10.022_bib39 article-title: Organ-specific mediation of lifespan extension: more than a gut feeling? publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2012.05.003 – volume: 7 start-page: 318 year: 2008 ident: 10.1016/j.isci.2018.10.022_bib9 article-title: Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor publication-title: Aging Cell doi: 10.1111/j.1474-9726.2008.00380.x – volume: 26 start-page: 183 year: 2014 ident: 10.1016/j.isci.2018.10.022_bib38 article-title: Age-related changes in small intestinal mucosa epithelium architecture and epithelial tight junction in rat models publication-title: Aging Clin. Exp. Res. doi: 10.1007/s40520-013-0148-0 – volume: 59 start-page: 51 year: 2015 ident: 10.1016/j.isci.2018.10.022_bib24 article-title: Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster publication-title: Invertebr. Reprod. Dev. doi: 10.1080/07924259.2014.963713 – volume: 6 start-page: 464 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib34 article-title: Anti-TNF-alpha antibodies improve intestinal barrier function in Crohn's disease publication-title: J. Crohns Colitis doi: 10.1016/j.crohns.2011.10.004 – volume: 14 start-page: 623 year: 2011 ident: 10.1016/j.isci.2018.10.022_bib40 article-title: Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog publication-title: Cell Metab. doi: 10.1016/j.cmet.2011.09.013 – volume: 22 start-page: 4645 year: 2016 ident: 10.1016/j.isci.2018.10.022_bib8 article-title: Intestinal barrier dysfunction in human pathology and aging publication-title: Curr. Pharm. Des. doi: 10.2174/1381612822666160510125331 – volume: 109 start-page: 21528 year: 2012 ident: 10.1016/j.isci.2018.10.022_bib41 article-title: Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1215849110 – volume: 10 start-page: 1 year: 2018 ident: 10.1016/j.isci.2018.10.022_bib6 article-title: Cell biology of tight junction barrier regulation and mucosal disease publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a029314 |
| SSID | ssj0002002496 |
| Score | 2.2833405 |
| Snippet | Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 229 |
| Title | Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30419503 https://www.proquest.com/docview/2132728427 https://pubmed.ncbi.nlm.nih.gov/PMC6231084 https://doaj.org/article/c6b56f09d47448789766f9856baeeb46 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYqTlyqVkCbtiAjcUNpQ-w49pGnEAKERJG4RX5M2gDyVmQ58O-ZcbKrXVTRS6-xo1jz8Hjib75hbCdgyPC47eVeVSGXovC4D0qTu-BtGwSYUlFx8sWlOr2RZ7fV7UKrL8KEDfTAg-B-eOUq1RYmyBoziVpj-FSt0ZVyFsDJRLaNMW8hmbpL12tEhZc6y1WECULTHCtmBnAXVbwSrkt_J2hXWS5FpUTe_7cT52vg5EIkOvnA3o9HSL4_LP0jewdxjV3Trz10Vxq5jvYe-vsu8lS-1POLLtEt4dDRc--6Sd_1fKhP5PvUpIjbGPhVAuZBz88n8RdQS4l1dnNy_PPwNB8bJuS-EnKaC-dA-lZSwarFTAEdzmqnRN1aKK1R2khXeVDox3taBQCoQ7BGCwh1IaURG2wlTiJ8ZlwWAVMx5zDjASlCa1qrtXU2qMJVotUZ25sJrPEjmzg1tXhoZrCxu4aE3JCQ6RkKOWO783f-DFwab84-ID3MZxIPdnqA1tGM1tH8yzoytj3TYoN-Q5chNsLkqW9KTMNrNNKyztinQavzT4lCUndckbF6Sd9La1keid3vxM2t6Lys5Zf_sfivbJXkMRBNfmMr08cn2MQj0NRtJWt_AUaaA60 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intestinal+Snakeskin+Limits+Microbial+Dysbiosis+during+Aging+and+Promotes+Longevity&rft.jtitle=iScience&rft.au=Salazar%2C+Anna+M.&rft.au=Resnik-Docampo%2C+Martin&rft.au=Ulgherait%2C+Matthew&rft.au=Clark%2C+Rebecca+I.&rft.date=2018-11-30&rft.issn=2589-0042&rft.eissn=2589-0042&rft.volume=9&rft.spage=229&rft.epage=243&rft_id=info:doi/10.1016%2Fj.isci.2018.10.022&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_isci_2018_10_022 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2589-0042&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2589-0042&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2589-0042&client=summon |