Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1

• Published in: Autophagy Vol. 18; no. 8; pp. 1864 - 1878
• Main Authors: Shao, Tong, Ke, Hanni, Liu, Ran, Xu, Lan, Han, Shuang, Zhang, Xiruo, Dang, Yujie, Jiao, Xue, Li, Wei, Chen, Zi-Jiang, Qin, Yingying, Zhao, Shidou
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.08.2022
• Subjects: Autophagy; differentiation; granulosa cells; premature ovarian insufficiency; Research Paper; WT1; differentiation; granulosa cells; premature ovarian insufficiency; WT1; Autophagy

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and this is indispensable for oocyte development and female fertility. Although the role of macroautophagy/autophagy in ovarian function has been reported, its contribution to the regulation of GC characteristi...