Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury

• Published in: Autophagy Vol. 13; no. 6; pp. 1080 - 1081
• Main Authors: Zhang, Weilin, Siraj, Sami, Zhang, Rong, Chen, Quan
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.06.2017
• Subjects: Autophagic Punctum; heart injury; hypoxic mitophagy; ischemia/reperfusion; mitochondrial quality; mitophagy receptor; platelets; ischemia/reperfusion; mitochondrial quality; hypoxic mitophagy; mitophagy receptor; heart injury; platelets

Mitophagy plays pivotal roles in the selective disposal of unwanted mitochondria, and accumulation of damaged mitochondria has been linked to aging-related diseases. However, definitive proof that mitophagy regulates mitochondrial quality in vivo is lacking. It is also largely unclear whether damage...