A Portable Fluorescence Camera for Testing Surgical Specimens in the Operating Room: Description and Early Evaluation
Purpose Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted op...
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| Published in | Molecular imaging and biology Vol. 13; no. 5; pp. 862 - 867 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer-Verlag
01.10.2011
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1536-1632 1860-2002 1860-2002 |
| DOI | 10.1007/s11307-010-0438-2 |
Cover
| Abstract | Purpose
Clinical translation of novel optical probes requires testing of human specimens
ex vivo
to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room.
Procedures
A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems.
Results
The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems.
Conclusion
We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes. |
|---|---|
| AbstractList | Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room.
A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems.
The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems.
We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes. Purpose Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room. Procedures A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems. Results The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems. Conclusion We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes. Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room. A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems. The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems. We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes.[PUBLICATION ABSTRACT] Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room.PURPOSEClinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room.A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems.PROCEDURESA compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems.The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems.RESULTSThe prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems.We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes.CONCLUSIONWe demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes. |
| Author | Mitsunaga, Makoto Kosaka, Nobuyuki Morgan, Nicole Y. Pohida, Thomas J. Choyke, Peter L. Kobayashi, Hisataka Kakareka, John W. McCann, Thomas E. |
| AuthorAffiliation | 2 Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B3B69, MSC1088, 10 Center Dr., Bethesda, MD 20892-1088, USA 3 Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Dr., Bethesda, MD 20892-5766, USA 1 Signal Processing and Instrumentation Section, Division of Computational Bioscience, Center of Information Technology, National Institutes of Health, 12 South Dr., Bethesda, MD 20892-5624, USA |
| AuthorAffiliation_xml | – name: 2 Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B3B69, MSC1088, 10 Center Dr., Bethesda, MD 20892-1088, USA – name: 3 Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Dr., Bethesda, MD 20892-5766, USA – name: 1 Signal Processing and Instrumentation Section, Division of Computational Bioscience, Center of Information Technology, National Institutes of Health, 12 South Dr., Bethesda, MD 20892-5624, USA |
| Author_xml | – sequence: 1 givenname: John W. surname: Kakareka fullname: Kakareka, John W. organization: Signal Processing and Instrumentation Section, Division of Computational Bioscience, Center of Information Technology, National Institutes of Health – sequence: 2 givenname: Thomas E. surname: McCann fullname: McCann, Thomas E. organization: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 3 givenname: Nobuyuki surname: Kosaka fullname: Kosaka, Nobuyuki organization: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 4 givenname: Makoto surname: Mitsunaga fullname: Mitsunaga, Makoto organization: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 5 givenname: Nicole Y. surname: Morgan fullname: Morgan, Nicole Y. organization: Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health – sequence: 6 givenname: Thomas J. surname: Pohida fullname: Pohida, Thomas J. organization: Signal Processing and Instrumentation Section, Division of Computational Bioscience, Center of Information Technology, National Institutes of Health – sequence: 7 givenname: Peter L. surname: Choyke fullname: Choyke, Peter L. organization: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health – sequence: 8 givenname: Hisataka surname: Kobayashi fullname: Kobayashi, Hisataka email: kobayash@mail.nih.gov organization: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20960235$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1364_BOE_3_001880 crossref_primary_10_1109_JSTQE_2011_2164900 crossref_primary_10_1038_srep27525 crossref_primary_10_18632_oncotarget_9898 crossref_primary_10_1002_cmmi_1705 crossref_primary_10_1038_srep12080 crossref_primary_10_18632_oncotarget_26320 crossref_primary_10_1098_rsta_2011_0300 |
| Cites_doi | 10.1117/1.2779351 10.1245/s10434-006-9194-6 10.1245/s10434-009-0594-2 10.1117/1.3378128 10.1007/PL00011356 10.1021/jm901228u 10.1038/nbt0806-909 10.2310/7290.2009.00009 10.1593/tlo.09157 |
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Clinical translation of novel optical probes requires testing of human specimens
ex vivo
to ensure efficacy. However, it may be difficult to remove... Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human... |
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| SubjectTerms | Animals Female Fluorescence Humans Imaging Medicine Medicine & Public Health Mice Operating Rooms Ovarian Neoplasms - pathology Photography Radiology Research Article Specimen Handling Transplantation, Heterologous |
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| Title | A Portable Fluorescence Camera for Testing Surgical Specimens in the Operating Room: Description and Early Evaluation |
| URI | https://link.springer.com/article/10.1007/s11307-010-0438-2 https://www.ncbi.nlm.nih.gov/pubmed/20960235 https://www.proquest.com/docview/893876624 https://www.proquest.com/docview/894818577 https://pubmed.ncbi.nlm.nih.gov/PMC3089711 |
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