Short-Term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes

• Published in: American journal of hypertension Vol. 18; no. 2; pp. 220 - 226
• Main Authors: Mangoni, Arduino A., Sherwood, Roy A., Asonganyi, Belinda, Swift, Cameron G., Thomas, Stephen, Jackson, Stephen H.D.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2005; Oxford University Press; Elsevier Science
• Subjects: Acetylcholine - pharmacology; Administration, Oral; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Associated diseases and complications; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - drug effects; Cardiology. Vascular system; Cardiovascular system; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Double-Blind Method; Drug Administration Schedule; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Folic acid; Folic Acid - administration & dosage; Folic Acid - blood; Folic Acid - therapeutic use; Forearm - blood supply; homocysteine; Homocysteine - antagonists & inhibitors; Homocysteine - blood; Humans; Male; Medical sciences; Middle Aged; Osmolar Concentration; Pharmacology. Drug treatments; Pulse; Regional Blood Flow - drug effects; type 2 diabetes; Vasodilation - drug effects; Vasodilator Agents - pharmacology; homocysteine; endothelium; type 2 diabetes; Folic acid; Endocrinopathy; Short term; Type 2 diabetes; Human; Hypertension; Thiol; Vitamin; Oral administration; Metabolic diseases; Cardiovascular disease; Endothelium; Sulfur containing aminoacid; Homocystein; Supplementation

Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial f...