Mercury-induced inflammation and autoimmunity

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 12; p. 129299
• Main Authors: Pollard, K. Michael, Cauvi, David M., Toomey, Christopher B., Hultman, Per, Kono, Dwight H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: Animal model; animal models; Animals; antibody formation; autoimmune diseases; Autoimmune Diseases - chemically induced; Autoimmune Diseases - genetics; Autoimmune Diseases - pathology; Autoimmunity; Autoimmunity - drug effects; cytokines; Cytokines - genetics; Cytokines - immunology; Disease Models, Animal; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; genes; Genome-Wide Association Study; Human; Humans; immune system; Inflammation; Inflammation - chemically induced; Inflammation - immunology; Inflammation - pathology; kidney diseases; Mercury; Mercury - toxicity; pathogenesis; Autoimmunity; Animal model; HMR1; UNC93B1; mHgIA; PHA; MHC; TNF; IFN; NLRP; CTLA4; TLR; ICOS; SLC15A4; Human; CD; IL; Con A; 4-1BB; Inflammation; AP3B1; PBMC; NFKB1; BCR; LAG; TACI; DAF1; IRF; Mercury

Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies and suitable diagnostic criteria, however, has hampered collection of sufficient data to support a causative role for mercury in autoimmune d...