Id family of helix-loop-helix proteins in cancer

• Published in: Nature reviews. Cancer Vol. 5; no. 8; pp. 603 - 614
• Main Authors: Perk, Jonathan, Iavarone, Antonio, Benezra, Robert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2005; Nature Publishing Group
• Subjects: Anaplasia - physiopathology; Biomarkers, Tumor; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell Proliferation; DNA binding proteins; Genetic aspects; Helix-Loop-Helix Motifs - physiology; Humans; Inhibitor of Differentiation Protein 1; Models, Animal; Neoplasms - physiopathology; Neovascularization, Pathologic - physiopathology; Oncogenes; Physiological aspects; Repressor Proteins - physiology; review-article; Transcription Factors - physiology; United States

Key Points Inhibitor of DNA binding (Id) family members are key regulatory proteins in a wide range of developmental and cellular processes and function by inhibiting target proteins that include the basic helix-loop-helix transcription factors, members of the Ets protein family and retinoblastoma....