Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression

• Published in: Thrombosis and haemostasis Vol. 93; no. 6; p. 1168
• Main Authors: Görlach, Agnes, BelAiba, Rachida S, Hess, John, Kietzmann, Thomas
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2005
• Subjects: 3-Phosphoinositide-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation - drug effects; Humans; Hypertension, Pulmonary - enzymology; MAP Kinase Kinase 3 - metabolism; MAP Kinase Signaling System; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - enzymology; Mutation; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Protein-Serine-Threonine Kinases - deficiency; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Artery - drug effects; Pulmonary Artery - enzymology; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Thrombin - pharmacology; Thromboplastin - metabolism; Transfection

The p21-activated serine/threonine kinases (PAK) play an important role in a variety of cellular functions. However, their role in the smooth muscle response to thrombin, which is activated upon vascular injury and promotes vascular remodelling processes, is not resolved. Here we investigated the ro...