Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects

• Published in: British journal of nutrition Vol. 110; no. 3; pp. 420 - 425
• Main Authors: Reyes-Izquierdo, Tania, Nemzer, Boris, Shu, Cynthia, Huynh, Lan, Argumedo, Ruby, Keller, Robert, Pietrzkowski, Zb
• Format: Journal Article
• Language: English
• Published: Cambridge Cambridge University Press 14.08.2013
• Subjects: Biological and medical sciences; blood; Brain; Brain-Derived Neurotrophic Factor - blood; Caffeine; Caffeine - pharmacology; clinical trials; Coffea - chemistry; Coffee; coffee beans; data collection; Extraction processes; Feeding. Feeding behavior; Fruit - chemistry; fruit extracts; Fruits; Fundamental and applied biological sciences. Psychology; grape seed extract; Health; Humans; Medical sciences; Neuropharmacology; Neuroses; Pharmacology. Drug treatments; placebos; Plant Extracts - pharmacology; Plasma; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Seeds; Silica; Silicon Dioxide; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitaceae; Vitis; Procyanidins; CNS stimulant; Fruit; Healthy subject; Nutrition; Psychotropic; Central nervous system; Extract; Coffee; Encephalon; Micronutrient; Brain-derived growth factor; Coffee fruit extract; Polyphenol; Polyphenols; Proanthocyanidin; Brain derived neurotrophic factor; Caffeine; Growth factor
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114512005338

The present single-dose study was performed to assess the effect of whole coffee fruit concentrate powder (WCFC), green coffee caffeine powder (N677), grape seed extract powder (N31) and green coffee bean extract powder (N625) on blood levels of brain-derived neurotrophic factor (BDNF). Randomly assorted groups of fasted subjects consumed a single, 100 mg dose of each material. Plasma samples were collected at time zero ( T 0 ) and at 30 min intervals afterwards, up to 120 min. A total of two control groups were included: subjects treated with silica dioxide (as placebo) or with no treatment. The collected data revealed that treatments with N31 and N677 increased levels of plasma BDNF by about 31 % under these experimental conditions, whereas treatment with WCFC increased it by 143 % ( n 10), compared with baseline. These results indicate that WCFC could be used for modulation of BDNF-dependent health conditions. However, larger clinical studies are needed to support this possibility.