Single-Cell ID-seq Reveals Dynamic BMP Pathway Activation Upstream of the MAF/MAFB-Program in Epidermal Differentiation

• Published in: iScience Vol. 9; pp. 412 - 422
• Main Authors: van Eijl, Roderick A.P.M., van Buggenum, Jessie A.G.L., Tanis, Sabine E.J., Hendriks, Joost, Mulder, Klaas W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 30.11.2018
• Subjects: Systems Biology; Stem Cells Research; Proteomics

Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and differentiation. These processes are controlled by both extracellular signaling and by cell intrinsic transcription regulatory networks, yet how these control mechanisms are integrated to achieve this is unclear. Her...