HLA-A32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 1; pp. 183 - 192
• Main Authors: Konvinse, Katherine C., Trubiano, Jason A., Pavlos, Rebecca, James, Ian, Shaffer, Christian M., Bejan, Cosmin A., Schutte, Ryan J., Ostrov, David A., Pilkinton, Mark A., Rosenbach, Misha, Zwerner, Jeffrey P., Williams, Kristina B., Bourke, Jack, Martinez, Patricia, Rwandamuriye, Francois, Chopra, Abha, Watson, Mark, Redwood, Alec J., White, Katie D., Mallal, Simon A., Phillips, Elizabeth J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Alleles; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - chemistry; antibiotic allergy; Antibiotics; Blood diseases; delayed hypersensitivity; Deoxyribonucleic acid; DNA; Drug Hypersensitivity Syndrome - etiology; Drug Hypersensitivity Syndrome - immunology; drug reaction with eosinophilia and systemic symptoms; Drug screening; E coli; Electronic medical records; Eosinophilia; Female; Gastrointestinal surgery; Histocompatibility antigen HLA; HLA-A Antigens - chemistry; HLA-A Antigens - immunology; human leukocyte antigen; Humans; Hypersensitivity; Lymphocytes T; Male; Middle Aged; Molecular Docking Simulation; Morbidity; Mortality; Patients; Software; Staphylococcus infections; T-cell hypersensitivity; Vancomycin; Vancomycin - adverse effects; Vancomycin - chemistry; Young Adult; DRESS; human leukocyte antigen; antibiotic allergy; drug reaction with eosinophilia and systemic symptoms; IDT; IRB; T-cell hypersensitivity; Vancomycin; delayed hypersensitivity; FOXP3; EHR; ADR

Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy, affecting future treatment choices. Variatio...