emPAI‐assisted strategy enhances screening and assessment of Mycobacterium tuberculosis infection serological markers

• Published in: Microbial biotechnology Vol. 14; no. 4; pp. 1827 - 1838
• Main Authors: Ma, Guorong, Wang, Pei, Yang, Yanhui, Wang, Wei, Ma, Jinhua, Zhou, Lin, Ouyang, Junlin, Li, Rongxiu, Zhang, Shulin
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2021; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Antibodies; Antigens; Antigens, Bacterial; Bacterial Proteins - genetics; Biomarkers; Chromatography, Liquid; E coli; Enzyme-linked immunosorbent assay; Filtrate; Functional groups; Gravy; Immunization; Immunogenicity; Infections; Infectious diseases; Mathematical analysis; Metabolism; Mice; Molecular weight; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Peptides; Proteins; Screening; Serology; Tandem Mass Spectrometry; Technical services; Tuberculosis; Tuberculosis - diagnosis; Virulence

Summary Discovering new serological markers of Mycobacterium tuberculosis (MTB) infection and establishing a rapid and efficient detection technology is of great significance for the prevention and control of tuberculosis. In this study, we established an exponentially modified protein abundance ind...