Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

• Published in: Diabetes, obesity & metabolism Vol. 14; no. 6; pp. 500 - 510
• Main Authors: Knop, F. K., Aaboe, K., Vilsbøll, T., Vølund, A., Holst, J. J., Krarup, T., Madsbad, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Beta cells; Biomarkers - blood; Blood glucose; Blood Glucose - metabolism; Body Mass Index; C-Peptide - blood; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Fasting; Fasting - blood; Female; Glucagon; Glucagon - blood; Glucagon-Like Peptide 1 - blood; Glucose; Glucose - metabolism; Glucose tolerance; Glucose Tolerance Test; Hormones; Humans; incretin effect; Incretins - blood; Insulin - blood; Insulin-Secreting Cells - metabolism; Male; Middle Aged; Obesity; Obesity - blood; Obesity - complications; Obesity - physiopathology; Objectives; Patients; type 2 diabetes

Aims: People with type 2 diabetes mellitus (T2DM) are characterized by reduced incretin effect and inappropriate glucagon levels. We evaluated α and β‐cell responses to oral glucose tolerance test (OGTT) and isoglycaemic intravenous glucose infusion (IIGI) in lean and obese persons with T2DM or norm...