Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants

• Published in: British journal of clinical pharmacology Vol. 68; no. 2; pp. 221 - 225
• Main Authors: Kwadijk‐de Gijsel, Sonja, Bijl, Monique J., Visser, Loes E., Van Schaik, Ron H. N., Hofman, Albert, Vulto, Arnold G., Van Gelder, Teun, Ch. Stricker, Bruno H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2009; Blackwell; Blackwell Science Inc
• Subjects: Aged; antidepressants; Antidepressive Agents - pharmacokinetics; Antidepressive Agents - therapeutic use; Biological and medical sciences; Cohort Studies; CYP2D6; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Genotype; Humans; hyponatraemia; Hyponatremia - chemically induced; Hyponatremia - metabolism; Male; Medical sciences; Pharmacogenetics; Pharmacology. Drug treatments; Polymorphism, Genetic - drug effects; Polymorphism, Genetic - genetics; SSRI; TCA; Human; Biological fluid; Hydroelectrolytic balance disorder; Pharmacogenetics; Hyponatremia; Enzyme; Isozyme; Psychotropic; Cytochrome P450; Variations; antidepressants; Inorganic element; Selective serotonin reuptake inhibitor; SSRI; Metabolic disorder; TCA; hyponatraemia; Gene; Sodium; CYP2D6; Antidepressant agent; Genetics; Serum

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Several antidepressants are metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). • The variant allele CYP2D6*4 is the main polymorphism resulting in decreased enzyme activity in Caucasians. • Decreased CYP2D6 enzyme activity potentially leads...