Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

• Published in: Circulation (New York, N.Y.) Vol. 140; no. 11; pp. 937 - 951
• Main Authors: Chothani, Sonia, Schäfer, Sebastian, Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A., Langley, Sarah R., Tan, Jessie, Wang, Mao, Quaife, Nicholas M., Jian Pua, Chee, D’Agostino, Giuseppe, Guna Shekeran, Shamini, George, Benjamin L., Lim, Stella, Yiqun Cao, Elaine, van Heesch, Sebastiaan, Witte, Franziska, Felkin, Leanne E., Christodoulou, Eleni G., Dong, Jinrui, Blachut, Susanne, Patone, Giannino, Barton, Paul J.R., Hubner, Norbert, Cook, Stuart A., Rackham, Owen J.L.
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 10.09.2019; Lippincott Williams & Wilkins
• Subjects: Cells, Cultured; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis - genetics; Fibrosis - metabolism; Fibrosis - pathology; Gene Expression Profiling - methods; Heart Diseases - genetics; Heart Diseases - metabolism; Heart Diseases - pathology; Humans; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Original s; Protein Biosynthesis - genetics; RNA-Binding Proteins - genetics; Sequence Analysis, RNA - methods; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; RNA-binding proteins; fibrosis; ribosome profiling; TGF-beta1; dilated cardiomyopathy

BACKGROUND:Fibrosis is a common pathology in many cardiac disorders and is driven by the activation of resident fibroblasts. The global posttranscriptional mechanisms underlying fibroblast-to-myofibroblast conversion in the heart have not been explored. METHODS:Genome-wide changes of RNA transcripti...