Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation

• Published in: Circulation (New York, N.Y.) Vol. 137; no. 10; pp. 1027 - 1038
• Main Authors: Weng, Lu-Chen, Preis, Sarah R., Hulme, Olivia L., Larson, Martin G., Choi, Seung Hoan, Wang, Biqi, Trinquart, Ludovic, McManus, David D., Staerk, Laila, Lin, Honghuang, Lunetta, Kathryn L., Ellinor, Patrick T., Benjamin, Emelia J., Lubitz, Steven A.
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 06.03.2018
• Subjects: Adult; Antihypertensive Agents - therapeutic use; Atrial Fibrillation - drug therapy; Atrial Fibrillation - epidemiology; Atrial Fibrillation - genetics; Cohort Studies; Community-Based Participatory Research; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Hypertension - drug therapy; Hypertension - epidemiology; Hypertension - genetics; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction - drug therapy; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide; Risk Factors; United States - epidemiology; United States; epidemiology; atrial fibrillation; genetics; risk stratification; lifetime risk; polygenic risk; risk factor

BACKGROUND:The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. METHODS:We estimated the lifetime risk of AF in individuals from the community-based Framingham Heart Study. Polygenic risk for AF was derived us...