A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon‐derived peptide levels

• Published in: Journal of diabetes investigation Vol. 14; no. 5; pp. 648 - 658
• Main Authors: Kobayashi, Masaki, Maruyama, Nobuhiro, Yamamoto, Yukako, Togawa, Takeshi, Ida, Takanori, Yoshida, Morikatsu, Miyazato, Mikiya, Kitada, Masahisa, Hayashi, Yoshitaka, Kashiwagi, Atsunori, Kitamura, Tadahiro
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.05.2023; John Wiley and Sons Inc; Wiley
• Subjects: Cloning; Diabetes; Diabetes Mellitus; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Gastrectomy; Gastrointestinal surgery; Glicentin; Glucagon; Glucose; Glucose Intolerance - diagnosis; Glucose tolerance; Humans; Intolerance; Laparoscopy; Liquid chromatography; Monoclonal antibodies; Obesity; Original; Pathophysiology; Peptide Hormones; Peptides; Plasma; Polypeptides; Proglucagon; Sandwich ELISA; United States > US; Japan; Glucagon; Sandwich ELISA; Glicentin

Aims/Introduction Glucagon, a peptide hormone produced from proglucagon, is involved in the pathophysiology of diabetes. Plasma glucagon levels are currently measured by sandwich enzyme‐linked immunosorbent assay (ELISA), but the currently used sandwich ELISA cross‐reacts with proglucagon‐derived pe...