Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects

• Published in: Circulation (New York, N.Y.) Vol. 143; no. 12; pp. 1224 - 1238
• Main Authors: Li, Wenzhu, Kessinger, Chase W., Orii, Makoto, Lee, Hang, Wang, Lang, Weinberg, Ido, Jaff, Michael R., Reed, Guy L., Libby, Peter, Tawakol, Ahmed, Henke, Peter K., Jaffer, Farouc A.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 23.03.2021
• Subjects: Animals; Blood Circulation - physiology; Endothelium, Vascular - pathology; Female; Humans; Male; Mice; Quality of Life; Treatment Outcome; Veins - pathology; Venous Thrombosis - physiopathology; fibrinolysis; postthrombotic syndrome; inflammation; thrombectomy; venous thrombosis

Up to 50% of patients with proximal deep vein thrombosis (DVT) will develop the postthrombotic syndrome characterized by limb swelling and discomfort, hyperpigmentation, skin ulcers, and impaired quality of life. Although catheter-based interventions enabling the restoration of blood flow (RBF) have...