AIM2 upregulation promotes metastatic progression and PD‐L1 expression in lung adenocarcinoma

• Published in: Cancer science Vol. 114; no. 1; pp. 306 - 320
• Main Authors: Zheng, Jing‐Quan, Lin, Che‐Hsuan, Lee, Hsun‐Hua, Chang, Wei‐Ming, Li, Li‐Jie, Su, Chia‐Yi, Lee, Kang‐Yun, Chiu, Hui‐Wen, Lin, Yuan‐Feng
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - pathology; AIM2 inflammasome; Apoptosis; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Breast cancer; cancer metastasis; Cell culture; Cell death; Comparative analysis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; epithelial‐mesenchymal transition; Gene expression; Genomes; Humans; Immune checkpoint; Inflammasomes; Inflammasomes - metabolism; Lung cancer; Lung Neoplasms - pathology; Medical prognosis; Melanoma; Metastases; Metastasis; Original; ORIGINAL ARTICLES; PD-L1 protein; PD‐L1; Prognosis; Proteins; RNA; RNA, Messenger - genetics; Stat1 protein; Statistical significance; Tumorigenesis; Tumors; Up-Regulation; lung cancer; PD-L1; epithelial-mesenchymal transition; AIM2 inflammasome; cancer metastasis

Cancer metastasis leading to the dysfunction of invaded organs is the main cause of the reduced survival rates in lung cancer patients. However, the molecular mechanism for lung cancer metastasis remains unclear. Recently, the increased activity of inflammasome appeared to correlate with the metasta...