Sensitive Determination of Barbiturates in Biological Matrix by Capillary Electrophoresis Using Online Large-Volume Sample Stacking

• Published in: Journal of forensic sciences Vol. 57; no. 3; pp. 813 - 819
• Main Authors: Fan, Liu-Yin, He, Ting, Tang, Yun-Yun, Zhang, Wei, Song, Chao-Jin, Zhao, Xia, Zhao, Xiao-Yu, Cao, Cheng-Xi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2012; Wiley Subscription Services, Inc
• Subjects: Acetonitriles; amobarbital; Animals; barbital; Barbiturates - blood; Body fluids; Buffers; Capillarity; capillary zone electrophoresis; Drugs; Electricity; Electrophoresis; Electrophoresis, Capillary - methods; Forensic engineering; forensic science; Forensic sciences; Forensic Toxicology; Hydrogen-Ion Concentration; Injections; large volume; Methanol; On-line systems; Online; phenobarbital; Poisoning; Polarity; Rats; Rats, Sprague-Dawley; sample stacking; secobarbital; Stacking; Standard deviation; China

:  In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large‐volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was appl...