Sensitive Determination of Barbiturates in Biological Matrix by Capillary Electrophoresis Using Online Large-Volume Sample Stacking

:  In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large‐volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was appl...

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Published inJournal of forensic sciences Vol. 57; no. 3; pp. 813 - 819
Main Authors Fan, Liu-Yin, He, Ting, Tang, Yun-Yun, Zhang, Wei, Song, Chao-Jin, Zhao, Xia, Zhao, Xiao-Yu, Cao, Cheng-Xi
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.2012
Wiley Subscription Services, Inc
Subjects
Acetonitriles
amobarbital
Animals
barbital
Barbiturates - blood
Body fluids
Buffers
Capillarity
capillary zone electrophoresis
Drugs
Electricity
Electrophoresis
Electrophoresis, Capillary - methods
Forensic engineering
forensic science
Forensic sciences
Forensic Toxicology
Hydrogen-Ion Concentration
Injections
large volume
Methanol
On-line systems
Online
phenobarbital
Poisoning
Polarity
Rats
Rats, Sprague-Dawley
sample stacking
secobarbital
Stacking
Standard deviation
China
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Abstract :  In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large‐volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 μg/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal‐to‐noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7‐, 169.7‐, 202.7‐, and 169.1‐fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.
AbstractList In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large‐volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 μg/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal‐to‐noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7‐, 169.7‐, 202.7‐, and 169.1‐fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.
In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large-volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 ...g/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal-to-noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7-, 169.7-, 202.7-, and 169.1-fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results. (ProQuest: ... denotes formulae/symbols omitted.)
:  In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large‐volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 μg/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal‐to‐noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7‐, 169.7‐, 202.7‐, and 169.1‐fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.
In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large-volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 mu g/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal-to-noise ratio=9). By using LVSS, the stacking was simply achieved at 171.7-, 169.7-, 202.7-, and 169.1-fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.
In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large-volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 μg/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal-to-noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7-, 169.7-, 202.7-, and 169.1-fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning investigation. In this study, an online large-volume sample stacking (LVSS) with polarity switching in capillary electrophoresis (CE) was applied for the sensitive determination of barbiturates. This technique involves injecting a large volume of sample into a capillary and removing the sample matrix plug out of the capillary by reversing the polarity. Quantitation limit obtained was 0.048, 0.057, 0.039, and 0.015 μg/mL for secobarbital, amobarbital, barbital, and phenobarbital (signal-to-noise ratio = 9). By using LVSS, the stacking was simply achieved at 171.7-, 169.7-, 202.7-, and 169.1-fold for the above four barbiturates. The relative standard deviation values of intraday and interday were <2.11% and 4.69%, respectively. Recoveries were ranged from 83.7 to 105.2%. Finally, the trace analysis method was applied to the analysis of real forensic specimens and has achieved satisfactory results.
Author Tang, Yun-Yun
Song, Chao-Jin
Zhao, Xiao-Yu
Cao, Cheng-Xi
He, Ting
Zhang, Wei
Zhao, Xia
Fan, Liu-Yin
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  organization: Laboratory of Analytical Biochemistry and Bioseparation, School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang, Shanghai 200240, China
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Álvarez-Llamas G, Rodríguez-Cea A, Fernández de la Campa MR, Sanz-Medel A. A large volume sample stacking capillary electrophoresis for metallothioneins analysis in eel liver. Anal Chim Acta 2003;486:183-90.
Quesada-Molina C, García-Campaña AM, del Olmo-Iruela L, del Olmo M. Large volume sample stacking in capillary zone electrophoresis for the monitoring of the degradation products of metribuzin in environmental samples. J Chromatogr A 2007;1164:320-8.
Morales S, Cela R. Field-amplified sample stacking and nonaqueous capillary electrophoresis determination of complex mixtures of polar aromatic sulfonates. Electrophoresis 2002;23:408-13.
Martín-Biosca Y, Molero-Monfort M, Sagrado S, Villanueva-Camañas RM, Medina-Hernández MJ. Development of predictive retention-activity relationship models of barbiturates by micellar liquid chromatography. Quant Struct-Act Rel 2000;19:247-56.
Cugat MJ, Borrull F, Calull M. Large-volume sample stacking for on-capillary sample enrichment in the determination of naphthalene and benzene sulfonates in real water samples by capillary zone electrophoresis. Analyst 2001;126:1312-7.
Kanazawa H, Konishi Y, Matsushima Y, Takahashi T. Determination of sedatives and anesthetics in plasma by liquid chromatography-mass spectrometry with a desalting system. J Chromatogr A 1998;797:227-36.
Zhou X, Fan LY, Zhang W, Cao CX. Separation and determination of acrylamide in potato chips by micellar electrokinetic capillary chromatography. Talanta 2007;71:1541-5.
Francotte E, Cherkaoui S, Faupel M. Separation of the enantimoers of some racemic nonsteroidal aromatase inhibitors and barbiturates by capillary electrophoresis. Chirality 1993;5:516-26.
Liu RH, McKeehan AM, Cinnamon BA, Foster G, Bensley WD, Laugner JG. Improved gas chromatography/mass spectrometry analysis of barbiturates in urine using centrifuge-based solid-phase extraction, methylation, with d5-pentobarbital as internal standard. J Forensic Sci 1994;39:1504-14.
Vlasses PH, Roccin ML, Koffer H, Ferguson RK. Combined phenytoin and phenobarbital overdose. Drug Intell Clin Pharm 1982;16:487-8.
Cannon RD, Wong SHY, Gock SB, Jentzen JJ. Comparison of the serum barbiturates fluorescence polarization immunoassay by the COBAS INTEGRA to a GC/MS method. Ther Drug Monit 1999;21:553-8.
Collison IB, Spiehler VR, Guluzian S, Sedgwick PR. Setting cutoff concentrations for immunoassay screening of postmortem blood. J Forensic Sci 1998;43:390-4.
Smyth WF, Harland GB, McClean S, McGrath G, Oxspring D. Effect of on-capillary large volume sample stacking on limits of detection in the capillary zone electrophoretic determination of selected drugs, dyes and metal chelates. J Chromatogr A 1997;772:161-9.
Li S, Weber SG. Determination of barbiturates by solid-phase microextraction and capillary electrophoresis. Anal Chem 1997;69:1217-22.
Liu B, Zhong X, Lu Y. Analysis of plant hormones in tobacco flowers by micellar electrokinetic capillary chromatography coupled with on-line large volume sample stacking. J Chromatogr A 2002;945:257-65.
Núñez O, Moyano E, Galceran MT. Solid-phase extraction and sample stacking-capillary electrophoresis for the determination of quaternary ammonium herbicides in drinking water. J Chromatogr A 2002;946:275-82.
Capella-Peiro ME, Gil-Agusti M, Martinavarro-Dominguez A, Esteve-Romeroa J. Determination in serum of some barbiturates using micellar liquid chromatography with direct injection. Anal Biochem 2002;309:261-8.
Coupey SM. Barbiturates. Pediatr Rev 1997;18:260-5.
Ohyama K, Wada M, Lord GA, Ohda Y, Fujishita O, Nakashima K, et al. Capillary electrochromatographic analysis of barbiturates in serum. Electrophoresis 2004;25:594-9.
Kuo CY, Chiou SS, Wu SM. Solid-phase extraction and large-volume sample stacking with an electroosmotic flow pump in capillary electrophoresis for determination of methotrexate and its metabolites in human plasma. Electrophoresis 2006;27:2905-9.
Iwai M, Hattori H, Arinobu T, Ishii A, Kumazawa T, Noguchi H, et al. Simultaneous determination of barbiturates in human biological fluids by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry. J Chromatogr B 2004;806:65-73.
Jiang TF, Wang YH, Lv ZH, Yue ME. Direct determination of barbiturates in urine by capillary electrophoresis using a capillary coated dynamically with polycationic polymers. Chromatographia 2007;65:611-5.
1982; 16
1996; 19
1997; 85
2007; 1164
2004; 25
1997; 69
2002; 772
1997; 772
1978; 132
1999; 21
1998; 797
2007; 71
1999; 20
1998; 43
2004; 806
2001; 126
1993; 5
1995; 40
2000; 19
1998; 19
2000; 14
2004; 18
2000; 15
2007; 594
2006; 27
2002; 23
1995; 703
1997; 18
2006; 580
2002; 946
2002; 309
1994; 39
2002; 945
1992; 64
2007; 65
2003; 486
1996; 735
2001; 73
1981; 53
e_1_2_6_31_2
e_1_2_6_30_2
e_1_2_6_18_2
e_1_2_6_19_2
Wilson JT (e_1_2_6_3_2) 1978; 132
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Collison IB (e_1_2_6_14_2) 1998; 43
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Vlasses PH (e_1_2_6_2_2) 1982; 16
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e_1_2_6_25_2
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Snippet :  In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning...
In China, some forensic cases are caused by barbiturates. Thus, the determination of trace level barbiturates in body fluid is important for the poisoning...
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SubjectTerms Acetonitriles
amobarbital
Animals
barbital
Barbiturates - blood
Body fluids
Buffers
Capillarity
capillary zone electrophoresis
Drugs
Electricity
Electrophoresis
Electrophoresis, Capillary - methods
Forensic engineering
forensic science
Forensic sciences
Forensic Toxicology
Hydrogen-Ion Concentration
Injections
large volume
Methanol
On-line systems
Online
phenobarbital
Poisoning
Polarity
Rats
Rats, Sprague-Dawley
sample stacking
secobarbital
Stacking
Standard deviation
Title Sensitive Determination of Barbiturates in Biological Matrix by Capillary Electrophoresis Using Online Large-Volume Sample Stacking
URI https://api.istex.fr/ark:/67375/WNG-XRW3KZCW-H/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1556-4029.2011.02034.x
https://www.ncbi.nlm.nih.gov/pubmed/22225534
https://www.proquest.com/docview/1010258352
https://www.proquest.com/docview/1016676037
https://www.proquest.com/docview/1022906626
Volume 57
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