Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

• Published in: The European journal of neuroscience Vol. 28; no. 2; pp. 389 - 398
• Main Authors: Ising, Marcus, Depping, Anna-Mareike, Siebertz, Anna, Lucae, Susanne, Unschuld, Paul G., Kloiber, Stefan, Horstmann, Sonja, Uhr, Manfred, Müller-Myhsok, Bertram, Holsboer, Florian
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2008
• Subjects: Adult; Alleles; Anxiety - etiology; chaperone protein; Female; Genetic Predisposition to Disease; Genotype; glucocorticoids; Heterozygote; Homozygote; HPA system; Humans; Hydrocortisone - blood; Male; Polymorphism, Genetic; Receptors, Glucocorticoid - genetics; Receptors, Mineralocorticoid - genetics; Recovery of Function; Recurrence; Stress, Psychological - blood; Stress, Psychological - genetics; Stress, Psychological - psychology; Tacrolimus Binding Proteins - genetics; Trier social stress test

Mood and anxiety disorders are considered stress‐related diseases characterized by an impaired function of mineralocorticoid and glucocorticoid receptors (MR and GR, respectively), the major regulatory elements of the hypothalamus–pituitary–adrenocortical (HPA) axis. A number of so‐called chaperone...