Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades

• Published in: Genes chromosomes & cancer Vol. 22; no. 1; pp. 9 - 15
• Main Authors: Ichimura, Koichi, Schmidt, Esther E., Miyakawa, Ayako, Goike, Helena M., Collins, V. Peter
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.05.1998
• Subjects: Astrocytoma - genetics; Astrocytoma - pathology; Chromosome Deletion; Chromosomes, Human, Pair 10 - genetics; Genes, Tumor Suppressor - genetics; Glioblastoma - genetics; Glioblastoma - pathology; Humans; Microsatellite Repeats; Neoplasm Recurrence, Local

Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are not coincident. We have deletion mapped chromosome 10 in 198 astrocytic gliomas using 53 microsatellite markers. Two commonly deleted regions...