Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are not coincident. We have deletion mapped chromosome 10 in 198 astrocytic gliomas using 53 microsatellite markers. Two commonly deleted regions...
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| Published in | Genes chromosomes & cancer Vol. 22; no. 1; pp. 9 - 15 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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01.05.1998
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| Abstract | Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are not coincident. We have deletion mapped chromosome 10 in 198 astrocytic gliomas using 53 microsatellite markers. Two commonly deleted regions on 10p were identified, one of which lies between D10S594 and D10S559 and the other between D10S1713 and D10S189. Most of 10q deletions were large and included a region distal to D10S554. Four glioblastomas of 122 had patterns suggestive of homozygous deletions at D10S541, a locus close and distally located to the PTEN/MMAC1 gene. Losses of alleles were found not only in glioblastomas (93%) but also in anaplastic astrocytomas (66%) and in astrocytomas (35%). Most glioblastomas lost one entire chromosome 10, while astrocytomas preferentially lost only 10p. The data suggest that a number of tumor suppressor genes on chromosome 10, in addition to PTEN/MMAC1, may be associated with astrocytic glioma development. Genes Chromosomes Cancer 22:9–15, 1998. © 1998 Wiley‐Liss, Inc. |
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| AbstractList | Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are not coincident. We have deletion mapped chromosome 10 in 198 astrocytic gliomas using 53 microsatellite markers. Two commonly deleted regions on 10p were identified, one of which lies between D10S594 and D10S559 and the other between D10S1713 and D10S189. Most of 10q deletions were large and included a region distal to D10S554. Four glioblastomas of 122 had patterns suggestive of homozygous deletions at D10S541, a locus close and distally located to the PTEN/MMAC1 gene. Losses of alleles were found not only in glioblastomas (93%) but also in anaplastic astrocytomas (66%) and in astrocytomas (35%). Most glioblastomas lost one entire chromosome 10, while astrocytomas preferentially lost only 10p. The data suggest that a number of tumor suppressor genes on chromosome 10, in addition to PTEN/MMAC1, may be associated with astrocytic glioma development. Genes Chromosomes Cancer 22:9–15, 1998. © 1998 Wiley‐Liss, Inc. Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are not coincident. We have deletion mapped chromosome 10 in 198 astrocytic gliomas using 53 microsatellite markers. Two commonly deleted regions on 10p were identified, one of which lies between D10S594 and D10S559 and the other between D10S1713 and D10S189. Most of 10q deletions were large and included a region distal to D10S554. Four glioblastomas of 122 had patterns suggestive of homozygous deletions at D10S541, a locus close and distally located to the PTEN/MMAC1 gene. Losses of alleles were found not only in glioblastomas (93%) but also in anaplastic astrocytomas (66%) and in astrocytomas (35%). Most glioblastomas lost one entire chromosome 10, while astrocytomas preferentially lost only 10p. The data suggest that a number of tumor suppressor genes on chromosome 10, in addition to PTEN/MMAC1, may be associated with astrocytic glioma development. |
| Author | Goike, Helena M. Collins, V. Peter Ichimura, Koichi Schmidt, Esther E. Miyakawa, Ayako |
| Author_xml | – sequence: 1 givenname: Koichi surname: Ichimura fullname: Ichimura, Koichi organization: Ludwig Institute for Cancer Research and Unit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden – sequence: 2 givenname: Esther E. surname: Schmidt fullname: Schmidt, Esther E. organization: Ludwig Institute for Cancer Research and Unit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden – sequence: 3 givenname: Ayako surname: Miyakawa fullname: Miyakawa, Ayako organization: Ludwig Institute for Cancer Research and Unit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden – sequence: 4 givenname: Helena M. surname: Goike fullname: Goike, Helena M. organization: Ludwig Institute for Cancer Research and Unit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden – sequence: 5 givenname: V. Peter surname: Collins fullname: Collins, V. Peter email: vpc@instpat.ks.se organization: Ludwig Institute for Cancer Research and Unit of Tumor Pathology, Department of Oncology and Pathology, Karolinska Hospital, 171 76 Stockholm, Sweden |
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| Cites_doi | 10.1006/geno.1996.0277 10.1002/gcc.2870070311 10.1002/gcc.2870050111 10.1126/science.275.5308.1943 10.1016/0360-3016(93)90203-8 10.1038/ng1095-210 10.1007/BF00219686 10.1111/j.1349-7006.1996.tb00231.x 10.1016/0888-7543(89)90302-9 10.1038/ng0497-356 10.1126/science.270.5244.1945 10.3171/jns.1992.77.2.0295 10.1002/gcc.2870120404 10.1038/bjc.1997.2 10.1038/380152a0 10.1002/gcc.2870050412 |
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| Snippet | Deletions of chromosome 10 are the most frequent genetic abnormality in glioblastomas. Several commonly deleted regions have been proposed; however, they are... |
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| SubjectTerms | Astrocytoma - genetics Astrocytoma - pathology Chromosome Deletion Chromosomes, Human, Pair 10 - genetics Genes, Tumor Suppressor - genetics Glioblastoma - genetics Glioblastoma - pathology Humans Microsatellite Repeats Neoplasm Recurrence, Local |
| Title | Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades |
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