Bariatric surgery induces pancreatic cell transdifferentiation as indicated by single‐cell transcriptomics in Zucker diabetic rats

• Published in: Journal of diabetes Vol. 16; no. 8; pp. e13521 - n/a
• Main Authors: Liang, Yongjun, Widjaja, Jason, Sun, Jiawei, Li, Mengyi, Qiao, Zhengdong, Cao, Ting, Wang, Yueqian, Zhang, Xiong, Zhang, Zhongtao, Gu, Yan, Zhang, Peng, Yang, Jianjun
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01.08.2024; John Wiley & Sons, Inc; Wiley
• Subjects: Animals; bariatric surgery; Bariatric Surgery - methods; Blood Glucose - metabolism; Cell Transdifferentiation - genetics; Diabetes; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - surgery; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - surgery; Gastrointestinal surgery; Glucose; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Male; Obesity - genetics; Obesity - metabolism; Obesity - surgery; Original; Pancreas - metabolism; Pancreas - pathology; pancreatic cell differentiation; Rats; Rats, Zucker; Single-Cell Analysis - methods; Transcriptome; type 2 diabetes mellitus; type 2 diabetes mellitus; pancreatic cell differentiation; bariatric surgery

Aims Bariatric surgery results in rapid recovery of glucose control in subjects with type 2 diabetes mellitus. However, the underlying mechanisms are still largely unknown. The present study aims to clarify how bariatric surgery modifies pancreatic cell subgroup differentiation and transformation in...