Triostin A Derived Cyclopeptide as Architectural Template for the Alignment of Four Recognition Units

• Published in: ChemistryOpen (Weinheim) Vol. 3; no. 4; pp. 152 - 160
• Main Authors: Kotyrba, Ursula M., Pröpper, Kevin, Sachs, Eike-F., Myanovska, Anastasiya, Joppe, Tobias, Lissy, Friederike, Sheldrick, George M., Koszinowski, Konrad, Diederichsen, Ulf
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2014; Blackwell Publishing Ltd
• Subjects: Amino acids; Biochemistry; ESI mass spectrometry; Mass spectrometry; microscale thermophoreses; nucleobase recognition; peptide nucleic acids; Quinoxalines; Recognition; structure characterization of biomolecules; Synthesis; Thermophoresis; triostin A; New York; United States > US; ESI mass spectrometry; structure characterization of biomolecules; triostin A; microscale thermophoreses; nucleobase recognition; peptide nucleic acids

The DNA bisintercalator triostin A is structurally based on a disulfide‐bridged depsipeptide scaffold that provides preorganization of two quinoxaline units in 10.5 Å distance. Triostin A analogues are synthesized with nucleobase recognition units replacing the quinoxalines and containing two additi...