Identification of essential β‐oxidation genes and corresponding metabolites for oestrogen degradation by actinobacteria

• Published in: Microbial biotechnology Vol. 15; no. 3; pp. 949 - 966
• Main Authors: Hsiao, Tsun‐Hsien, Lee, Tzong‐Huei, Chuang, Meng‐Rong, Wang, Po‐Hsiang, Meng, Menghsiao, Horinouchi, Masae, Hayashi, Toshiaki, Chen, Yi‐Lung, Chiang, Yin‐Ru
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2022; John Wiley and Sons Inc; Wiley
• Subjects: Actinobacteria - genetics; Actinobacteria - metabolism; Activated sludge; Bacteria - metabolism; Biodegradation; Cholesterol; Cleavage; Coenzyme A; Contaminants; Dehydrogenases; Disruption; Ecosystem; Enzymes; Estrogens; Estrogens - metabolism; Estrone; Estuaries; Gene disruption; Gene expression; Genes; Genetic engineering; Genomes; Liquid chromatography; Livestock; Mass spectrometry; Mass spectroscopy; Metabolites; Microorganisms; Oxidation; Oxygenase; Photodegradation; Polymerase chain reaction; Rhodococcus; Sediments; Soil; Soil contamination; Soil pollution; Soils; Spectroscopy; Steroids; Testosterone; Thiolase; Transcriptomes; Transcriptomics; Xenoestrogens

Summary Steroidal oestrogens (C18) are contaminants receiving increasing attention due to their endocrine‐disrupting activities at sub‐nanomolar concentrations. Although oestrogens can be eliminated through photodegradation, microbial function is critical for removing oestrogens from ecosystems devo...