Protection of Eurasian badgers ( Meles meles ) from tuberculosis after intra-muscular vaccination with different doses of BCG

• Published in: Vaccine Vol. 29; no. 21; pp. 3782 - 3790
• Main Authors: Lesellier, Sandrine, Palmer, Si, Gowtage-Sequiera, Sonya, Ashford, Roland, Dalley, Deanna, Davé, Dipesh, Weyer, Ute, Salguero, F. Javier, Nunez, Alejandro, Crawshaw, Timothy, Corner, Leigh A.L, Hewinson, R. Glyn, Chambers, Mark A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 12.05.2011; Elsevier; Elsevier Limited
• Subjects: adults; Allergy and Immunology; Animals; Applied microbiology; badgers; Baits; BCG Vaccine - administration & dosage; Biological and medical sciences; bovine tuberculosis; Cattle; cell-mediated immunity; control methods; Disease; Disease control; Disease Reservoirs - microbiology; disease severity; excretion; Experiments; Female; Fundamental and applied biological sciences. Psychology; herds; Histology; humans; Immune response; Immunity, Cellular; Immunology; Infections; Injections, Intramuscular - veterinary; interferon-gamma; Interferon-gamma - blood; Interferon-gamma - immunology; Male; Meles meles; Microbiology; Mustelidae - microbiology; Mycobacterium bovis; Mycobacterium bovis - immunology; Mycobacterium bovis - isolation & purification; Mycobacterium bovis BCG; Pathology; Tuberculosis; Tuberculosis - immunology; Tuberculosis - pathology; Tuberculosis - prevention & control; Tuberculosis - veterinary; Vaccination; Vaccination - veterinary; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); virulence; Wildlife; Wildlife conservation; Irish Republic; Great Britain; Pathology; Tuberculosis; Immunology; Wildlife; Vaccination; Fissipedia; Carnivora; Vertebrata; Mammalia; Meles meles; BCG; Wild animal

Abstract Mycobacterium bovis infection is widespread in Eurasian badger ( Meles meles ) populations in Great Britain and the Republic of Ireland where they act as a wildlife reservoir of infection for cattle. Removal of infected badgers can significantly reduce the incidence of bovine tuberculosis (...