Hindlimb unweighting alters endothelium-dependent vasodilation and ecNOS expression in soleus arterioles

• Published in: Journal of applied physiology (1985) Vol. 89; no. 4; pp. 1483 - 1490
• Main Authors: Schrage, William G, Woodman, Christopher R, Laughlin, M. Harold
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.10.2000; American Physiological Society
• Subjects: Acetylcholine - pharmacology; Animals; Arterioles - drug effects; Arterioles - physiology; Biological and medical sciences; Blood vessels; Blood vessels and receptors; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Enzymologic - drug effects; Gene Expression Regulation, Enzymologic - physiology; Hindlimb Suspension; In Vitro Techniques; Indomethacin - pharmacology; Male; Muscle, Skeletal - blood supply; Muscular system; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type III; Nitroarginine - pharmacology; Nitroprusside - pharmacology; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Rodents; Space life sciences; Transcription, Genetic - drug effects; Transcription, Genetic - physiology; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: cardiovascular system; Regional blood flow; Rat; Enzyme; Arteriole; Rodentia; Environmental factor; Weightlessness; Gene expression; Nitric-oxide synthase; Vasodilation; Endothelium; Microcirculation; Vertebrata; Mammalia; Vascular resistance; Simulation; Dysfunction; Circulatory system; Hemodynamics; Oxidoreductases; Microgravity; NASA Discipline Cardiopulmonary; Non-NASA Center

Departments of Physiology and Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211 The purpose of this study was to test the hypothesis that endothelium-dependent dilation is impaired in soleus resistance arteries from hindlimb-un...