Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons

• Published in: Biological psychiatry (1969) Vol. 85; no. 10; pp. 850 - 862
• Main Authors: Boldrini, Maura, Galfalvy, Hanga, Dwork, Andrew J., Rosoklija, Gorazd B., Trencevska-Ivanovska, Iskra, Pavlovski, Goran, Hen, René, Arango, Victoria, Mann, J. John
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2019
• Subjects: Adolescent; Adult; Adverse Childhood Experiences; Dentate Gyrus - pathology; Depressive Disorder, Major - complications; Depressive Disorder, Major - pathology; Depressive Disorder, Major - psychology; Female; Granule cell; Humans; Major depression; Male; Middle Aged; Neural progenitors; Neural Stem Cells - pathology; Neuroglia - pathology; Neurons - pathology; Postmortem; Psychiatric/Mental Health; Resilience, Psychological; Stress; Suicide; Suicide - psychology; Young Adult; Granule cell; Suicide; Major depression; Neural progenitors; Stress; Postmortem

Early life adversity (ELA) increases major depressive disorder (MDD) and suicide risk and potentially affects dentate gyrus (DG) plasticity. We reported smaller DG and fewer granular neurons (GNs) in MDD. ELA effects on DG plasticity in suicide decedents with MDD (MDDSui) and resilient subjects (ELA...