Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

• Published in: Autophagy Vol. 5; no. 8; pp. 1131 - 1144
• Main Authors: Song, Jianrui, Qu, Zengqiang, Guo, Xianling, Zhao, Qiudong, Zhao, Xue, Gao, Lu, Sun, Kai, Shen, Feng, Wu, Mengchao, Wei, Lixin
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 16.11.2009
• Subjects: Adenine - analogs & derivatives; Adenine - pharmacology; Apoptosis - drug effects; Apoptosis Regulatory Proteins - metabolism; Autophagy - drug effects; Beclin-1; Binding; Biology; Bioscience; Calcium; Cancer; Carcinoma, Hepatocellular - pathology; Cell; Cell Cycle - drug effects; Cell Hypoxia - drug effects; Cisplatin - pharmacology; Cycle; Drug Resistance, Neoplasm - drug effects; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; Green Fluorescent Proteins - metabolism; Hep G2 Cells; Humans; Landes; Liver Neoplasms - pathology; Membrane Proteins - metabolism; Organogenesis; Proteins

Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated a protective way to make hepatocellular carcinoma cells be resi...