Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells
Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated a protective way to make hepatocellular carcinoma cells be resi...
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| Published in | Autophagy Vol. 5; no. 8; pp. 1131 - 1144 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Taylor & Francis
16.11.2009
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| Online Access | Get full text |
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| Abstract | Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated a protective way to make hepatocellular carcinoma cells be resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agents-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed i.e. chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential. |
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| AbstractList | Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated a protective way to make hepatocellular carcinoma cells be resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agents-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed i.e. chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential. Hypoxia commonly exists in solid tumors. Under such adverse conditions, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated as a protective way to make hepatocellular carcinoma cells resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agent-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed, i.e., chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential.Hypoxia commonly exists in solid tumors. Under such adverse conditions, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated as a protective way to make hepatocellular carcinoma cells resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agent-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed, i.e., chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential. Hypoxia commonly exists in solid tumors. Under such adverse conditions, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated as a protective way to make hepatocellular carcinoma cells resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agent-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed, i.e., chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential. |
| Author | Shen, Feng Song, Jianrui Guo, Xianling Zhao, Xue Gao, Lu Qu, Zengqiang Wu, Mengchao Zhao, Qiudong Sun, Kai Wei, Lixin |
| Author_xml | – sequence: 1 givenname: Jianrui surname: Song fullname: Song, Jianrui – sequence: 2 givenname: Zengqiang surname: Qu fullname: Qu, Zengqiang – sequence: 3 givenname: Xianling surname: Guo fullname: Guo, Xianling – sequence: 4 givenname: Qiudong surname: Zhao fullname: Zhao, Qiudong – sequence: 5 givenname: Xue surname: Zhao fullname: Zhao, Xue – sequence: 6 givenname: Lu surname: Gao fullname: Gao, Lu – sequence: 7 givenname: Kai surname: Sun fullname: Sun, Kai – sequence: 8 givenname: Feng surname: Shen fullname: Shen, Feng – sequence: 9 givenname: Mengchao surname: Wu fullname: Wu, Mengchao – sequence: 10 givenname: Lixin surname: Wei fullname: Wei, Lixin email: lixinwei@smmu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19786832$$D View this record in MEDLINE/PubMed |
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| Snippet | Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. In... Hypoxia commonly exists in solid tumors. Under such adverse conditions, adaptive responses including autophagy are usually provoked to promote cell survival.... |
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| SubjectTerms | Adenine - analogs & derivatives Adenine - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Autophagy - drug effects Beclin-1 Binding Biology Bioscience Calcium Cancer Carcinoma, Hepatocellular - pathology Cell Cell Cycle - drug effects Cell Hypoxia - drug effects Cisplatin - pharmacology Cycle Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Gene Knockdown Techniques Green Fluorescent Proteins - metabolism Hep G2 Cells Humans Landes Liver Neoplasms - pathology Membrane Proteins - metabolism Organogenesis Proteins |
| Title | Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells |
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