Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 3898
• Main Authors: Kaihara, Kenta, Nakagawa, Shuji, Arai, Yuji, Inoue, Hiroaki, Tsuchida, Shinji, Fujii, Yuta, Kamada, Yoichiro, Kishida, Tsunao, Mazda, Osam, Takahashi, Kenji
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.04.2021; MDPI
• Subjects: Angiogenesis; Arthritis; Cartilage; Collagen; Cytokines; Deferoxamine; Destruction; Feedback; HIF-1 alpha; Hypoxia; Hypoxia-inducible factor 1a; Immunization; Inflammation; Joints (anatomy); Negative feedback; Pathogenesis; Proteins; Rheumatoid arthritis; Risk groups; Transcription; Tumor necrosis factor-TNF; hypoxia; rheumatoid arthritis; HIF-1 alpha

Hypoxia inducible factor (HIF)-1α has been implicated in the pathogenesis of rheumatoid arthritis (RA). HIF-1α, which is expressed in hypoxia, is reversely suppressed in sustained hypoxia. Here, we investigated the inhibitory effect of hypoxia on arthritis by controlling HIF-1α. Rheumatoid fibroblas...