EEG spectral analysis of nighttime sleep and daytime MSLTs and neurocognitive evaluations in subjects with co-morbid insomnia and OSA

• Published in: Respiratory research Vol. 26; no. 1; pp. 139 - 13
• Main Authors: Shi, Yuan, Nie, Yuru, Hao, Fengyi, Feng, Xujun, Zhang, Ye, Sanford, Larry D., Ren, Rong, Tang, Xiangdong
• Format: Journal Article
• Language: English
• Published: London BioMed Central 13.04.2025; BioMed Central Ltd; BMC
• Subjects: Adult; Cognition; Cognition - physiology; Cohort Studies; COMISA; Comorbidity; Electroencephalography; Electroencephalography - methods; Female; Health aspects; Humans; Insomnia; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Middle Aged; Multiple sleep latency test; Nervous system; Neurocognition; Neurophysiology; Neuropsychological Tests; Physiological aspects; Pneumology/Respiratory System; Polysomnography; Polysomnography - methods; Sleep; Sleep - physiology; Sleep apnea syndromes; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - epidemiology; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - psychology; Sleep Initiation and Maintenance Disorders - diagnosis; Sleep Initiation and Maintenance Disorders - epidemiology; Sleep Initiation and Maintenance Disorders - physiopathology; Sleep Initiation and Maintenance Disorders - psychology; Sleep Latency - physiology; Spectral analysis; China; COMISA; Neurocognition; Polysomnography; Multiple sleep latency test; Spectral analysis; Neurophysiology
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/s12931-025-03193-x

Background Chronic insomnia and obstructive sleep apnea commonly co-occur. Few studies have explored the neurophysiological and neurocognitive characteristics of COMISA, which could help guide improving treatment diagnostic tools and determining novel therapeutic targets. This study aims to explore the neurophysiological and neurocognitive characteristics of COMISA using electroencephalographic (EEG) spectral analysis and subjective and objective neurocognitive measurements. Methods Participants were from our community recruited OSA-insomnia-COMISA cohort with 206 included for our current analysis including 74 chronic insomniacs (CIs), 55 OSA patients and 77 COMISA patients. Standard polysomnography (PSG) and multiple sleep latency tests (MSLTs) were recorded and used to obtain relative EEG spectral power in each sleep stage during PSG and each session during MSLTs. A series of subjective and objective neurocognitive tests were conducted to evaluate executive function, attention, retrospective and prospective memory and meta-cognition. Results In PSG and MSLTs, COMISA patients showed combined EEG power characteristics of both CIs and OSA. Specifically, COMISA patients exhibited similar EEG spectral characteristics to CIs, with decreased delta and increased alpha and beta power in NREM sleep stages, and increased beta power in REM and MSLTs. Similar to the EEG spectral power profile of OSA, COMISA patients showed increased delta power in REM and MSLTs. Compared to OSA patients, COMISA patients exhibited worse subjectively measured attention and meta-cognition related to negative beliefs about uncontrollability and danger of worry (NEG), which were positively associated with ISI scores. Conclusions The EEG spectral power characteristics of COMISA patients in overnight PSG and daytime MSLT appear to be the manifestation of elements of both CIs and OSA. However, the neurocognitive features of COMISA patients in subjectively measured attention and NEG meta-cognition were primarily affected by chronic insomnia.