Aspirin-Resistant Thromboxane Biosynthesis and the Risk of Myocardial Infarction, Stroke, or Cardiovascular Death in Patients at High Risk for Cardiovascular Events

• Published in: Circulation (New York, N.Y.) Vol. 105; no. 14; pp. 1650 - 1655
• Main Authors: Eikelboom, John W., Hirsh, Jack, Weitz, Jeffrey I., Johnston, Marilyn, Yi, Qilong, Yusuf, Salim
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09.04.2002; American Heart Association, Inc
• Subjects: Aged; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Aspirin - therapeutic use; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Canada - epidemiology; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - metabolism; Case-Control Studies; Cohort Studies; Comorbidity; Cyclooxygenase Inhibitors - therapeutic use; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - prevention & control; Demography; Female; Follow-Up Studies; Humans; Male; Medical sciences; Myocardial Infarction - epidemiology; Myocardial Infarction - prevention & control; Odds Ratio; Pharmacology. Drug treatments; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Secondary Prevention; Stroke - epidemiology; Stroke - prevention & control; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - urine; Thromboxanes - biosynthesis; Thromboxanes - urine; Vitamin E - therapeutic use; Canada; Human; Nervous system diseases; Stroke; Treatment resistance; Prognosis; Infarct; Arachidonic acid derivatives; Cardiovascular disease; Acetylsalicylic acid; Coronary heart disease; Myocardial disease; Antiplatelet agent; Cerebral disorder; Vascular disease; Chemotherapy; Treatment; Central nervous system disease; Myocardium; Salicylates; Thromboxane; Cerebrovascular disease

Background — We studied whether aspirin resistance, defined as failure of suppression of thromboxane generation, increases the risk of cardiovascular events in a high-risk population. Methods and Results — Baseline urine samples were obtained from 5529 Canadian patients enrolled in the Heart Outcome...