Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida

• Published in: Journal of ethnopharmacology Vol. 89; no. 1; pp. 171 - 175
• Main Authors: Choi, Eun-Mi, Hwang, Jae-Kwan
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.11.2003; Elsevier
• Subjects: Analgesic activity; analgesic effect; Analgesics - pharmacology; Animals; Anti-Allergic Agents - pharmacology; Anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; arthritis; Biological and medical sciences; ears; edema; Flowers; Fruit; General pharmacology; hypersensitivity; inflammation; Medical sciences; Medicinal plant; Mice; Mice, Inbred ICR; oral administration; pain; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Physalis; Physalis angulata; Piper; Piper cubeba; plant extracts; Plant Extracts - pharmacology; Rosa; Anti-inflammatory activity; Analgesic activity; Medicinal plant; Allergy; Rosaceae; Rosa; Antiallergic; Pain; Dicotyledones; Angiospermae; Solanaceae; Phytotherapy; Flower; Fruit; Pharmacognosy; Physalis; Rodentia; Antiinflammatory agent; Piperaceae; Inflammation; Vertebrata; Mammalia; Analgesic; Treatment; Mouse; Animal; Plant origin; Spermatophyta; Piper
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(03)00280-0

The anti-inflammatory activities of Piper cubeba (fruit), Physalis angulata (flower) and Rosa hybrida (flower) were determined by carrageenan-induced paw edema, arachidonic acid-induced ear edema and formaldehyde-induced arthritis in mice. The anti-allergic and analgesic activities of these plants were also studied by using 2,4-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity reaction (type IV) and hot plate test in mice, respectively. These plant extracts clearly exhibited inhibitory effects against acute and subacute inflammation by oral administration (200 mg/kg). Also, administration (200 mg/kg, p.o.) of plant extracts for 1 week significantly inhibited type IV allergic reaction in mice ( P<0.05). Rosa hybrida showed an analgesic effect against hot plate-induced thermal stimulation at a dose of 200 mg/kg. These results provide support for the use of Rosa hybrida in relieving inflammatory pain, and insight into the development of new agents for treating inflammatory diseases.