Breast cancer diagnosis using spatial light interference microscopy

• Published in: Journal of biomedical optics Vol. 20; no. 11; p. 111210
• Main Authors: Majeed, Hassaan, Kandel, Mikhail E, Han, Kevin, Luo, Zelun, Macias, Virgilia, Tangella, Krishnarao, Balla, Andre, Popescu, Gabriel
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.11.2015
• Subjects: Breast - pathology; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Equipment Design; Female; Humans; Image Interpretation, Computer-Assisted - methods; Microscopy, Interference - instrumentation; Microscopy, Interference - methods; Tissue Array Analysis - methods; label-free imaging; histopathology; breast cancer; microscopy; spatial light interference microscopy; quantitative phase imaging

The standard practice in histopathology of breast cancers is to examine a hematoxylin and eosin (H&E) stained tissue biopsy under a microscope to diagnose whether a lesion is benign or malignant. This determination is made based on a manual, qualitative inspection, making it subject to investiga...