The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis

• Published in: Laboratory investigation Vol. 98; no. 12; pp. 1600 - 1613
• Main Authors: Wang, Zhuo, Li, Jia'an, Xiao, Wen'ang, Long, Jiafu, Zhang, Hongmin
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.12.2018; Nature Publishing Group US; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/2; 13/31; 13/51; 13/95; 14/19; 631/154/556; 64/60; 692/699/1503/1607/1605; 82/29; 82/80; 96/21; Actin; AKT protein; Aminosalicylic Acids - pharmacology; Aminosalicylic Acids - therapeutic use; Angiogenesis; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Benzenesulfonates - pharmacology; Benzenesulfonates - therapeutic use; Bile; Carbon tetrachloride; Cell cycle; Cell Line; Cell proliferation; Collagen (type I); Deoxyribonucleic acid; Dimerization; DNA; Drug Synergism; Fibrosis; Hepatic Stellate Cells - drug effects; Humans; Inhibitors; Laboratory Medicine; Liver; Liver cancer; Liver Cirrhosis - prevention & control; Male; Medicine; Medicine & Public Health; Mice, Inbred BALB C; Neovascularization, Physiologic - drug effects; Organic chemistry; Pathology; Phosphorylation; Primary Cell Culture; Receptor, Transforming Growth Factor-beta Type II - metabolism; Smad2 protein; Smad3 protein; Sorafenib - pharmacology; Stat3 protein; STAT3 Transcription Factor - antagonists & inhibitors; Stellate cells; Synergistic effect; Tissue inhibitor of metalloproteinase 1; Transcription; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism

Liver fibrosis is a common pathological response to chronic hepatic injury. STAT3 is actively involved in the fibrogenesis and angiogenesis seen in liver fibrosis. S3I-201 (NSC 74859) is a chemical inhibitor of STAT3 activity, which blocks the dimerization of STAT3, STAT3-DNA binding and transcripti...