Rethinking progesterone regulation of female reproductive cyclicity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 15; pp. 4212 - 4217
• Main Authors: Kubota, Kaiyu, Cui, Wei, Dhakal, Pramod, Wolfe, Michael W., Rumi, M. A. Karim, Vivian, Jay L., Roby, Katherine F., Soares, Michael J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.04.2016; National Acad Sciences
• Subjects: Animals; Biological Sciences; Exons; Female; Females; Fertility; Ligands; Luteinizing Hormone - antagonists & inhibitors; Mifepristone - pharmacology; Mutation; Progesterone - genetics; Progesterone - physiology; Rats; Reproduction - physiology; Sexual behavior; Transcription factors; PGR; rat; reproductive cycles; progesterone

The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in the regulation of female fertility. Much has been learned of the actions of PGR signaling through the use of pharmacologic inhibitors and genetic manipulation, using mouse mutagenesis. Characterization of ra...