Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity

• Published in: Therapeutic advances in respiratory disease Vol. 17; p. 17534666231181262
• Main Authors: Lynn, Heather, Sun, Xiaoguang, Casanova, Nancy G., Bime, Christian, Reyes Hernon, Vivian, Lanham, Clayton, Oita, Radu C., Ramos, Nikolas, Sun, Belinda, Coletta, Dawn K., Camp, Sara M., Karnes, Jason H., Ellis, Nathan A., Garcia, Joe G.N.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2023; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Cytokines - genetics; Cytokines - metabolism; Endothelial Cells - metabolism; Humans; Lipopolysaccharides; Lung - metabolism; Nicotinamide Phosphoribosyltransferase - genetics; Nicotinamide Phosphoribosyltransferase - metabolism; Original Research; Plasma; Protein expression; Proteins; Respiratory Distress Syndrome - diagnosis; Respiratory Distress Syndrome - genetics; genotype–phenotype; extracellular nicotinamide phosphoribosyltransferase (eNAMPT); luciferase reporter; acute respiratory distress syndrome (ARDS); enzyme-linked immunosorbent assay

Background and objectives: eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity. This study assesses the previously unknown influence of NAMPT promoter SNPs on NAMPT...